{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:01:25Z","timestamp":1790262085025,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>The long\u2010term outcome in patients with craniopharyngiomas treated with fractionated stereotactic radiotherapy (FSRT) was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>A total of 40 patients with craniopharyngiomas were treated between May 1989 and July 2006 with FSRT. Most patients were treated for tumor progression after surgery. A median target dose of 52.2 grays (Gy) (range, 50.4\u201356 Gy) was applied in a median conventional fractionation of 5 \u00d7 1.8 Gy per week. Follow\u2010up examinations included thorough clinical assessment as well as contrast\u2010enhanced magnetic resonance imaging scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>After a median follow\u2010up of 98 months (range, 3\u2013326 months), local control was 100% at both 5 years and 10 years. Overall survival rates at 5 years and 10 years were 97% and 89%, respectively. A complete response was observed in 4 patients and partial responses were noted in 25 patients. Eleven patients presented with stable disease during follow\u2010up. Acute toxicity was mild in all patients. Long\u2010term toxicity included enlargement of cysts requiring drainage 3 months after FSRT. No visual impairment, radionecrosis, or development of secondary malignancies were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>The long\u2010term outcome of FSRT for craniopharyngiomas is excellent with regard to local control as well as treatment\u2010related side effects. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22703","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T16:53:53Z","timestamp":1177692833000},"page":"2308-2314","source":"Crossref","is-referenced-by-count":94,"title":["Achievement of long\u2010term local control in patients with craniopharyngiomas using high precision stereotactic radiotherapy"],"prefix":"10.1002","volume":"109","author":[{"given":"Stephanie E.","family":"Combs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Thilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Hoess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Schulz\u2010Ertner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1980.52.5.0661"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.89.4.0547"},{"issue":"1","key":"e_1_2_5_4_2","first-page":"289","article-title":"Epidemiological aspects of craniopharyngioma","volume":"19","author":"Haupt R","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"e_1_2_5_5_2","first-page":"1441","article-title":"Craniopharyngioma: prognostic importance of histologic features","volume":"17","author":"Petito CK","year":"1996","journal-title":"AJNR Am J Neuroradiol."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197604)37:4<1944::AID-CNCR2820370446>3.0.CO;2-#"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120867"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90005-9"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120866"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.1.0047"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000061227"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)81101-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02888-2"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200111000-00005"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)03029-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601118"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0003"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.2.0237"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.30.4.0377"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196010000-00013"},{"key":"e_1_2_5_21_2","first-page":"145","article-title":"Preliminary results of intracavitary treatment of craniopharyngioma with bleomycin","volume":"33","author":"Broggi G","year":"1989","journal-title":"J Neurosurg Sci."},{"key":"e_1_2_5_22_2","first-page":"303","article-title":"Results of treatment for craniopharyngioma","volume":"6","author":"Mori K","year":"1980","journal-title":"Childs Brain."},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199412000-00001"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.50.5.0617"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1961.18.2.0217"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.103.1.44"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.5.0648"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.4.0496"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90019-5"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90039-B"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01570-0"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.034"},{"key":"e_1_2_5_33_2","first-page":"163","article-title":"[Treatment of craniopharyngiomas in children. 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