{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:29:14Z","timestamp":1791120554348,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T00:00:00Z","timestamp":1182297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Although studies comparing conventional imaging modalities with <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (<jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET) for the detection of lymphoma and although the relations between <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET and histologic types were reported previously, most studies were not systematic and involved relatively small numbers of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Two hundred fifty\u2010five patients with lymphoma had their disease staged using <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET, and 191 of those patients also were assessed using gallium\u201067 scintigraphy (<jats:sup>67<\/jats:sup>Ga). Disease sites were identified on a site\u2010by\u2010site basis using computed tomography scans and\/or magnetic resonance imaging. The results of these conventional imaging modalities were compared with the results from <jats:sup>8<\/jats:sup>F\u2010FDG\u2010PET and <jats:sup>67<\/jats:sup>Ga, and correlations between the imaging results and pathologic diagnoses were evaluated by using the World Health Organization classification system.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Of 913 disease sites in 255 patients, <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET identified &gt;97% of disease sites of Hodgkin lymphoma (HL) and aggressive and highly aggressive non\u2010Hodgkin lymphoma. For indolent lymphoma, the detection rate of <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET was 91% for follicular lymphoma (FL); 82% for extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue, irrespective of plasmacytic differentiation; and approximately 50% for small lymphocytic lymphoma (SLL) and splenic marginal zone lymphoma (SMZL). The results from <jats:sup>67<\/jats:sup>Ga were similar to those from <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET for most histologic subtypes. However, the sensitivity of <jats:sup>67<\/jats:sup>Ga was unexpectedly poor for FL, for mantle cell lymphoma (MCL), and for the nasal type of natural killer\/T\u2010cell lymphoma (NK\/T\u2010nasal), ranging from 30% to 38%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET was useful for all histologic subtypes of lymphoma other than SLL and SMZL. Compared with <jats:sup>67<\/jats:sup>Ga, the authors strongly recommend the use of <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET in patients with FL, MCL, and NK\u2010nasal. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22807","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T13:47:16Z","timestamp":1182347236000},"page":"652-659","source":"Crossref","is-referenced-by-count":180,"title":["The usefulness of <sup>18<\/sup>F\u2010fluorodeoxyglucose positron emission tomography (<sup>18<\/sup>F\u2010FDG\u2010PET) and a comparison of <sup>18<\/sup>F\u2010FDG\u2010pet with <sup>67<\/sup>gallium scintigraphy in the evaluation of lymphoma"],"prefix":"10.1002","volume":"110","author":[{"given":"Norifumi","family":"Tsukamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Oriuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Yokohama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05069.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2004.03.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21253"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000340"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.9.3522.bloodjournal8693522"},{"key":"e_1_2_6_7_2","first-page":"1326","article-title":"The role of PET in lymphoma","volume":"47","author":"Jhanwa YS","year":"2006","journal-title":"J Nucl Med."},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1182\/blood.V88.8.3056.bloodjournal8883056","article-title":"Modulation of in vitro and in vivo T\u2010cell responses by transferring\u2010gallium and gallium citrate","volume":"88","author":"Drobyski WR","year":"1996","journal-title":"Blood."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880615)61:12<2439::AID-CNCR2820611208>3.0.CO;2-Q"},{"key":"e_1_2_6_10_2","first-page":"40","article-title":"67Ga scintigraphy in B\u2010cell non\u2010Hodgkin's lymphoma: correlation of 67Ga uptake with histology and transferring receptor expression","volume":"40","author":"Nejmeddine F","year":"1999","journal-title":"J Nucl Med."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10336"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04617.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1325-2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010301)91:5<889::AID-CNCR1078>3.0.CO;2-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050275"},{"key":"e_1_2_6_16_2","volume-title":"World Health Organization Classification of Tumors. 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