{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:36:32Z","timestamp":1760297792482,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T00:00:00Z","timestamp":1182124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>According to the American Joint Commission on Cancer (AJCC, 5<jats:sup>th<\/jats:sup> edition) classification system, pT4 N0 oral cavity squamous cell carcinoma (OSCC) qualifies for stage IVA status, with its implied poor prognosis. However, preliminary observations suggested that patients with pT4 N0 OSCC might have better survival than other stage IVA categories. The authors sought to identify accurate prognosticators in patients with stage III\/IVA OSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>The authors retrospectively reviewed 513 consecutive patients with stage III\/IVA OSCC who were undergoing radical surgery. Survival was plotted by Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>One hundred seventy\u2010eight patients were in stage III, and 335 were in stage IVA. The 335 stage IVA patients were divided into pT4 N0 (n = 105) and pT4 N1\/TAny N2 (NO pT4 N0 M0, n = 230). By univariate analysis, 5\u2010year neck control rates (<jats:italic>P<\/jats:italic> &lt; .0001), distant metastases (<jats:italic>P<\/jats:italic> &lt; .0001), disease\u2010free survival rates (<jats:italic>P<\/jats:italic> &lt; .0001), and overall survival rates (<jats:italic>P<\/jats:italic> &lt; .0001) were significantly different in pT4 N0 compared with NO pT4 N0 patients. No significant difference in survival between pT4 N0 stage IVA and pstage III could be shown. Multivariate analysis for overall survival demonstrated that the following factors were independently associated with pT4 N0: tumor depth \u226535 mm, vessel invasion, lymph invasion, and perineural invasion. In contrast, tumor depth \u226525 mm, treatment with surgery alone, poor differentiation, extracapsular spread, and pathological nodal metastases (\u22658 lymph nodes) were independent predictors of overall survival in NO pT4 N0.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>In patients with stage IVA OSCC (AJCC, 1997), the survival rates for pT4 N0 are better than those for NO pT4 N0 and similar to those of patients with pstage III. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22814","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T11:51:49Z","timestamp":1182167509000},"page":"564-571","source":"Crossref","is-referenced-by-count":53,"title":["Survival in squamous cell carcinoma of the oral cavity"],"prefix":"10.1002","volume":"110","author":[{"given":"Chun\u2010Ta","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Tung\u2010Chieh","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Hang","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuen","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Yu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010How","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiang\u2010Fu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Joy","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,18]]},"reference":[{"volume-title":"AJCC Cancer Staging Manual","year":"1997","author":"Fleming ID","key":"e_1_2_5_2_2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00430-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10570"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.11.020"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21984"},{"key":"e_1_2_5_8_2","first-page":"1339","article-title":"[Relationship between TNM\u2010classification and survival rate in cases of carcinoma of the oral cavity: a comparison between UICC and AJCC TNM staging system]","volume":"32","author":"Kamata S","year":"1986","journal-title":"Gan No Rinsho."}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:23:01Z","timestamp":1760271781000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22814"}},"subtitle":["Differences between pT4 N0 and other stage IVA categories"],"short-title":[],"issued":{"date-parts":[[2007,6,18]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/cncr.22814"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22814","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2007,6,18]]}}}