{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:17:41Z","timestamp":1786681061441,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T00:00:00Z","timestamp":1185494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Approximately 20% of patients who have hepatoblastoma (HB) still have unresectable disease after preoperative chemotherapy (POC). In these circumstances, orthotopic liver transplantation (OLT) should be performed 1 month after POC. The authors sought to identify presenting features that would predict unresectability in patients with HB and to provide suggestions for early referral and listing for OLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Notes, radiology films, and histology from patients who were treated over the previous 20 years were reviewed. Unfeasible resection was defined by bilobar involvement, vascular extension, and metastatic disease after POC. Failed conservative treatment (FCT) was used to categorize patients who were not disease\u2010free with their native liver \u22651 year after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Of 28 patients who were studied, 14 patients underwent resection, and 10 patients required OLT. Four patients did not undergo any type of surgery because of tumor progression. Overall, the 5\u2010year survival rate was 76% (95% confidence interval, 54.8\u201389%). Predictors of FCT were multifocality (<jats:italic>P<\/jats:italic> = .006), a high pretreatment extent of tumor (PRETEXT) score (III or IV; <jats:italic>P<\/jats:italic> = .006), portal vein involvement (<jats:italic>P<\/jats:italic> = .02), hepatic vein involvement (<jats:italic>P<\/jats:italic> = .02), or vena cava involvement (<jats:italic>P<\/jats:italic> = .05). Patients who achieved a curative resection presented at a younger age (median, 0.7 years vs 4.2 years, <jats:italic>P<\/jats:italic> = .02). Patients who had multifocal lesions and those who had an \u03b1\u2010fetoprotein (\u03b1FP) level &lt;100 ng\/mL survived only if they underwent transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Patients with HB who were managed by combined chemotherapy and surgery has a high survival rate. Older patients who had multifocal tumors, high PRETEXT scores, involvement of major liver vessels, and \u03b1FP levels &lt;100 ng\/mL were less likely to achieve curative resection. These findings at presentation should lead the clinicians to liaise early with a transplantation center. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.22876","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T12:16:52Z","timestamp":1185538612000},"page":"1050-1058","source":"Crossref","is-referenced-by-count":33,"title":["Features predicting unresectability in hepatoblastoma"],"prefix":"10.1002","volume":"110","author":[{"given":"Lorenzo","family":"D'Antiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vallortigara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Talenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Zancan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dall'Igna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca De","family":"Salvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Perilongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00049-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90762-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820334"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20607.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.09.011"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10376"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10282"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.145"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","article-title":"A simple estimate of glomerular filtration rate in children from body length and plasma creatinine","volume":"58","author":"Schwartz GJ","year":"1976","journal-title":"J Pediatr."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3819"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.06.003"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00015"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.14.2665"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00018-8"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00074-5"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.10.091"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30264"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20061"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.08.001"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10177"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.035"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10107"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.004"},{"key":"e_1_2_5_26_2","first-page":"404","article-title":"Initial low alphafoetoprotein level predicts a bad prognosis in high risk hepatoblastoma\u2014treatment results of two consecutive trials SIOPEL 2 and SIOPEL 3 of the childhood liver strategy group of the International Society of Pediatric Oncology","volume":"45","author":"Zsiros J","year":"2005","journal-title":"Pediatr Blood Cancer."},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000124387.87757.eb"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01003.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00017"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001015)89:8<1845::AID-CNCR27>3.0.CO;2-D"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.22876","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.22876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:34:58Z","timestamp":1760297698000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.22876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/cncr.22876"],"URL":"https:\/\/doi.org\/10.1002\/cncr.22876","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]}}}