{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:00:24Z","timestamp":1791046824635,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:00:00Z","timestamp":1187049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)\u2010negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate. In some patients, CCA\/Ph\u2010negative status was associated with myelodysplasia or acute myeloid leukemia. The objective of the current study was to determine the prognostic impact of CCA\/Ph\u2010negative cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>The authors compared the pretherapeutic risk factors (Kruskall\u2010Wallis test), exposure to cytotoxic drugs (chi\u2010square test), and overall and progression\u2010free survival (Kaplan\u2010Meyer and logistic regression analysis, respectively) of 515 patients with mostly chronic\u2010phase CML who were treated with imatinib mesylate after failure of interferon\u2010\u03b1 according to whether they attained a major cytogenetic response (MCR) (n = 324 patients), an MCR with CCA\/Ph\u2010negative status (n = 30 patients), or no MCR (n = 161 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>CCA\/Ph\u2010negative status most frequently involved chromosomes Y, 8, and 7. No significant differences in pretherapeutic risk factors were detected between patients who attained an MCR with and without CCA\/Ph\u2010negative cells, except that exposure to alkylating agents was more frequent in patients with CCA\/Ph\u2010negative cells, and overall and progression\u2010free survival were identical. With a median follow\u2010up of 51 months, only 2 patients developed myelodysplastic syndromes (MDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>The overall prognosis for patients who had CML with CCA\/Ph\u2010negative status was good and was driven by the CML response to imatinib mesylate. Isolated CCA\/Ph\u2010negative cells in the absence of morphologic evidence of MDS do not justify a change in therapy. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.22936","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T11:16:22Z","timestamp":1187090182000},"page":"1509-1519","source":"Crossref","is-referenced-by-count":110,"title":["The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome\u2010negative cells"],"prefix":"10.1002","volume":"110","author":[{"given":"Michael W. N.","family":"Deininger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Paquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hochhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Baccarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietger","family":"Niederwieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gambacorti\u2010Passerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insa","family":"Gathmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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