{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:52:08Z","timestamp":1787503928406,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T00:00:00Z","timestamp":1188172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>The objective of the current study was to identify variables that were predictive of cancer\u2010specific survival in patients with nonmetastatic transitional cell carcinoma of the upper urinary tract (UUT\u2010TCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>Clinical and pathologic data from 269 patients who underwent nephroureterectomy for UUT\u2010TCC from 1989 to 2005 in 3 urologic European centers were collected retrospectively. Log\u2010rank tests and Cox proportional\u2010hazards regression models were used for univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>Two hundred fifty patients underwent nephroureterectomy, and 19 patients underwent concomitant cystectomy for synchronous muscle\u2010invasive bladder cancer. The median follow\u2010up of the whole cohort was 34 months, and the median follow\u2010up of the patients who remained alive and disease\u2010free was 52 months. At follow\u2010up, 57 cancer\u2010related deaths (21.2%) were censored, and 169 patients (62.8%) were alive and disease\u2010free. On univariate analysis, a history of previous bladder cancer, pathologic stage of the primary tumor and lymph nodes, tumor grade, the presence of lymphovascular invasion, tumor site, synchronous muscle\u2010invasive bladder TCC, and tumor multifocality were associated with cancer\u2010specific survival probabilities. On multivariate analysis, pathologic stage of the primary tumor and lymph nodes, tumor multifocality within the UUT, synchronous muscle\u2010invasive bladder TCC, and a history of bladder TCC before the diagnosis of UUT\u2010TCC were independent predictors of cancer\u2010specific survival probabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>In a multi\u2010institutional dataset of patients who had undergone nephroureterectomy for UUT\u2010TCC, the current results indicated that pathologic stage of the primary tumor and lymph nodes, a history of prior bladder TCC, the presence of synchronous muscle\u2010invasive bladder cancer, and tumor multifocality within the UUT were independent predictors of cancer\u2010specific survival probabilities. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.22970","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T13:17:38Z","timestamp":1188220658000},"page":"1715-1722","source":"Crossref","is-referenced-by-count":167,"title":["Independent predictors of cancer\u2010specific survival in transitional cell carcinoma of the upper urinary tract"],"prefix":"10.1002","volume":"110","author":[{"given":"Giacomo","family":"Novara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedra","family":"Gottardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orietta","family":"Dalpiaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianney","family":"Bouygues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Galfano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Martignoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Patard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Artibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ficarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00230-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67019-X"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00295-7"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(92)90450-B"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00012-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.94"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000144505.40915.98"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.11.001"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.009"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00511-8"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000473758","article-title":"Prognostic factors of primary transitional cell carcinoma of the upper urinary tract","volume":"29","author":"Lee SH","year":"1996","journal-title":"Eur Urol."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_5_15_2","volume-title":"World Health Organization Classification of Tumors. 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