{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:16:20Z","timestamp":1774084580573,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T00:00:00Z","timestamp":1189036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow\u2010up has tended to be short. Furthermore, the different therapeutic strategies used in these patients has made it difficult to assess survival rates and prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>In 1989, a prospective Phase II trial was initiated to evaluate the efficacy of treatment for adults with MB. Patients were staged completely with a neuroradiologic examination of the brain and neuroaxis and by cerebrospinal fluid cytology, according to Chang's staging system. Low\u2010risk patients received radiotherapy alone, whereas high\u2010risk patients received 2 cycles of upfront chemotherapy followed by radiotherapy and adjuvant chemotherapy. The current article reports on the long\u2010term results from that trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>After a median follow up of 7.6 years, among a total of 36 adults with MB, the overall progression\u2010free survival (PFS) and overall survival (OS) rates at 5 years were 72% and 75%, respectively. In low\u2010risk patients, the 5\u2010year PFS rate was 80%, and the 5\u2010year OS rate was 80%; in high\u2010risk patients, the 5\u2010year PFS rate was 69%, and the 5\u2010year OS rate was 73%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>In adult patients with MB, long\u2010term follow\u2010up was essential for evaluating the real impact of treatments. Low\u2010risk and high\u2010risk patients did not differ significantly in terms of PFS or OS. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23003","type":"journal-article","created":{"date-parts":[[2007,9,6]],"date-time":"2007-09-06T11:46:31Z","timestamp":1189079191000},"page":"2035-2041","source":"Crossref","is-referenced-by-count":128,"title":["Long\u2010term results of a prospective study on the treatment of medulloblastoma in adults"],"prefix":"10.1002","volume":"110","author":[{"given":"Alba A.","family":"Brandes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Tosoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Blatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Ermani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02986-3"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90148-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00643-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/93.6.1351"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(90)90017-N"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.8.2939"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.1998.0096"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2003.08.005"},{"key":"e_1_2_5_10_2","first-page":"99","article-title":"Current and future strategies in the management of medulloblastoma in adults","volume":"13","author":"Kortmann RD","year":"2003","journal-title":"Forum (Genova)."},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4980"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941015)74:8<2352::AID-CNCR2820740821>3.0.CO;2-H"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00476-2"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200009000-00018"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-3-1-29"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006133404936"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.832"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950250303"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00369-7"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.116"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.23003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.23003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:21:03Z","timestamp":1760278863000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.23003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,18]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/cncr.23003"],"URL":"https:\/\/doi.org\/10.1002\/cncr.23003","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,18]]}}}