{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:17:04Z","timestamp":1789964224431,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T00:00:00Z","timestamp":1195084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Findings that statins inhibited the proliferation of breast cancer cells in vitro and in rodents have raised interest in whether the use of statins might decrease a woman's risk of developing breast cancer. We analyzed data from a population\u2010based case\u2010control study to evaluate the association between the use of statins and breast cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Cases of incident invasive breast cancer in women 50 years of age or older and diagnosed from 1995\u20132001 were identified from population\u2010based cancer registries in Wisconsin, Massachusetts, and New Hampshire. Controls were randomly selected, within each state, from lists of licensed drivers and Medicare beneficiaries. Information on the use of statins and other breast cancer risk factors was ascertained from structured telephone interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Overall, breast cancer cases were not more likely than controls to have ever used statins. Ever use of lipophilic statins as a group (simvastatin, lovastatin, and fluvastatin) and ever use of the hydrophilic statin pravastatin were also not associated with breast cancer risk. Ever use of fluvastatin was associated with a decreased risk of breast cancer (odds ratio [OR], 0.5; 95% confidence interval, 0.3\u20130.8) but the magnitude of the ORs did not vary across categories of duration of use.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>The use of statins overall was not associated with breast cancer risk. Cancer 2008. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23129","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T19:30:03Z","timestamp":1195155003000},"page":"27-33","source":"Crossref","is-referenced-by-count":54,"title":["Statin use and risk of breast cancer"],"prefix":"10.1002","volume":"112","author":[{"given":"Gaia","family":"Pocobelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Trentham\u2010Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Titus\u2010Ernstoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Hampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550040069040"},{"key":"e_1_2_5_3_2","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration. Electronic Orange Book. Approved Drug Products with Therapeutic Equivalence Evaluations. Available at URL:http:\/\/www.fda.gov\/cder\/ob\/default.htm; August2006."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.5414\/CPP42695"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4061"},{"key":"e_1_2_5_6_2","first-page":"111","article-title":"A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo","volume":"53","author":"Klement H","year":"2006","journal-title":"Neoplasma."},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530250059028"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7045"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.9882"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1649"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.5392"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0097"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.23.2720-a"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0027"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01147-4"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00299.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj188"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20271"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.17.2105"},{"key":"e_1_2_5_20_2","volume-title":"The Analysis of Case\u2010Control Studies","author":"Breslow NE","year":"1980"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0737"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.19.2264"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00614-5"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600267"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.15.2363"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200205000-00005"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.027"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20758"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/154099903322447710"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351401"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391902"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11600-X"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2998"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.20.1615"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16936-5"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh038"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.23129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.23129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:08:38Z","timestamp":1760270918000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.23129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,15]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/cncr.23129"],"URL":"https:\/\/doi.org\/10.1002\/cncr.23129","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,15]]}}}