{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:11:10Z","timestamp":1791051070727,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T00:00:00Z","timestamp":1193788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Most pilocytic astrocytomas (piloA) are benign growths (World Health Organization [WHO] grade 1) of the deep midline structures, the brainstem, and the cerebellum. To the authors' knowledge, the literature contains only scarce data regarding piloA in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between 1995 and 2005, 44 patients (26 women and 18 men) underwent surgery for a primary or recurrent piloA at the authors' institution. All patients were aged &gt; 16 years (mean \u00b1 standard deviation: 31 \u00b1 14 years) at the time of their first surgery. The histopathologic diagnoses were reviewed, and relevant clinical information was obtained through a chart review and telephone interviews. The mean follow\u2010up was 76 \u00b1 59 months (range, 1\u2013227 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were 20 patients (45%) with supratentorial lobar piloA (including 10 temporal\/temporomesial tumors, 5 parietal tumors, 3 insular tumors, 1 frontal tumor, and 1 occipital tumors), 12 patients with cerebellar piloA, 7 patients with brainstem piloA, 2 patients with opticochiasmatic PiloA, 1 patient with intramedullary piloA, and 2 patients with piloA of the basal ganglia. All but 1 patient with a lobar tumor presented with epilepsy. In 6 of 44 patients (14%), increased proliferative activity was revealed. WHO grade 3 primary anaplastic piloA was diagnosed in 2 patients (5%), and WHO grade 3 secondary anaplastic piloA was diagnosed in 4 patients (9%). Tumor recurrence or disease progression was observed in 13 of 44 patients (30%). Eight of 44 patients (18%) died from their disease. Histologic grading and extent of surgical resection proved to be important predictors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>PiloA in adult patients, surprisingly, often was not a benign disease. The degree of surgical resection was found to be of major importance for the patient's further clinical course; therefore, an aggressive surgical resection should be attempted whenever possible. Cancer 2007. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23148","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T12:50:19Z","timestamp":1193835019000},"page":"2799-2808","source":"Crossref","is-referenced-by-count":124,"title":["Frequent recurrence and progression in pilocytic astrocytoma in adults"],"prefix":"10.1002","volume":"110","author":[{"given":"Carsten","family":"St\u00fcer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Vilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Majores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,31]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Statistical Report: Primary Brain Tumors in the United States, 1998\u20132002","author":"Central Brain Tumor Registry U.S.","year":"2005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.6.1170"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401227"},{"key":"e_1_2_6_5_2","first-page":"45","volume-title":"Pathology and Genetics of Tumours of the Nervous System","author":"Burger PC","year":"2000"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000097266.89676.25"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199910000-00004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1335::AID-CNCR2820720431>3.0.CO;2-E"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-002-0828-y"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000121218"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003810050419"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.3.0484"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.5.0863"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.1.0056"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900317"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832355"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.020"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688690400022896"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.4.423"},{"key":"e_1_2_6_20_2","first-page":"152","article-title":"Clinicopathological analysis of pilocytic astrocytomas and gangliogliomas in children","volume":"37","author":"Fiks T","year":"1999","journal-title":"Folia Neuropathol."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-1546-z"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01406492"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.6.0811"},{"key":"e_1_2_6_24_2","first-page":"83","article-title":"Cerebellar pilocytic astrocytomas in children. 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