{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:33Z","timestamp":1770823953827,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Inhibitor of DNA binding 2 (Id2), a helix\u2010loop\u2010helix protein of the inhibitor of differentiation (ID) family, is involved in hematopoiesis, mainly through interaction with the E\u2010family of transcription factors. Recent studies have shown that Id2 is overexpressed in some types of B\u2010cell lymphoma, including classical Hodgkin lymphoma. The authors of the current study hypothesized that Id2 also is overexpressed in T\u2010cell lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>By using reverse\u2010transcriptase polymerase chain reaction (RT\u2010PCR) and Western blot analyses, high <jats:italic>Id2<\/jats:italic> messenger RNA (mRNA) and protein levels, respectively, were detected in all 4 T\u2010cell anaplastic large cell lymphoma (ALCL) cell lines that were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Immunohistochemistry results indicated that Id2 was expressed strongly in 21 of 27 (78%) ALCL tumors (79% anaplastic lymphoma kinase [ALK]\u2010negative and 75% ALK\u2010positive), in 5 of 10 (50%) extranodal natural killer\/T (NK\/T)\u2010cell lymphomas of the nasal type, in 2 of 8 (25%) cutaneous ALCLs, in 2 of 9 (22%) enteropathy type T\u2010cell lymphomas, in 1 of 5 (20%) peripheral T\u2010cell lymphomas not otherwise specified, and in 1 of 8 (13%) T\u2010cell prolymphocytic leukemias. Other types of T\u2010cell lymphoma were negative for Id2. Because it is known that myc is expressed in ALCL, myc was inhibited selectively in 2 ALCL cell lines, resulting in a concentration\u2010dependent decrease in <jats:italic>Id2<\/jats:italic> mRNA and protein levels. Conversely, forced expression of myc in HEK 293T cells using an myc\/green fluorescent protein adenoviral vector resulted in Id2 up\u2010regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>Taken together, the current data suggest that Id2 commonly is overexpressed in highly proliferative T\u2010cell lymphomas, and its expression may result from transcriptional activation of myc in these tumors. Cancer 2008. \u00a9 2007 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23196","type":"journal-article","created":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T16:18:20Z","timestamp":1197908300000},"page":"552-561","source":"Crossref","is-referenced-by-count":14,"title":["The helix\u2010loop\u2010helix protein Id2 is expressed differentially and induced by myc in T\u2010cell lymphomas"],"prefix":"10.1002","volume":"112","author":[{"given":"Claudiu V.","family":"Cotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Leventaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Atsaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Vidaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Schlette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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