{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:35:43Z","timestamp":1791362143276,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Onycholysis occurs in approximately 30% of patients treated with docetaxel. The efficacy and safety of an Elasto\u2010Gel frozen sock (FS) was investigated for the prevention of docetaxel\u2010induced nail and skin toxicity of the feet.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients receiving docetaxel at a dose of 70 to 100 mg\/m<jats:sup>2<\/jats:sup> every 3 weeks were eligible for this matched case\u2010control study. Each patient wore an FS for 90 minutes on the right foot. The unprotected left foot acted as control. Nail and skin toxicities were assessed using National Cancer Institute Common Toxicity Criteria (version 3) and compared using a 2\u2010sample Wilcoxon matched\u2010pairs rank test adjusted for tied values.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fifty consecutive patients were included between April 2005 and January 2007. Nail toxicity was significantly lower in the FS\u2010protected foot compared with the control foot (grade 0: 100% versus 79%; and grade 1 and 2: 0% versus 21%, respectively) (<jats:italic>P<\/jats:italic> = .002). Skin toxicity was grade 0: 98% versus 94%; and grade 1 and 2: 2% versus 6% in the FS\u2010protected and the control feet, respectively. The median times until toxicity occurrence were not found to differ significantly between the groups. One patient experienced discomfort because of cold intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Cold therapy using FS significantly reduced the incidence of docetaxel\u2010induced foot nail toxicity, as previously demonstrated using frozen gloves for the hands. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23333","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T14:56:08Z","timestamp":1203432968000},"page":"1625-1631","source":"Crossref","is-referenced-by-count":97,"title":["Matched case\u2010control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel\u2010induced onycholysis and cutaneous toxicity of the foot"],"prefix":"10.1002","volume":"112","author":[{"given":"Florian","family":"Scott\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniu","family":"Banu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Medioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Ebenezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Marsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Banu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Marc","family":"Tourani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Andrieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Oudard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02074-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.314"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.6.1238"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.11.2301"},{"key":"e_1_2_5_6_2","first-page":"141","article-title":"Paclitaxel (Taxol): a review of its antitumor activity in clinical studies","volume":"43","author":"Hajek R","year":"1996","journal-title":"Neoplasma."},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000026486.56886.18"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg050"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001040-00004"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0232-0"},{"key":"e_1_2_5_11_2","first-page":"334","article-title":"The irreplaceable image: nails changes in onco\u2010hematologic patients","volume":"86","author":"Vassallo C","year":"2001","journal-title":"Haematologica."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018132"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.651"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.99.147"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.016"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02967619"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-4-200508160-00021"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00012-5"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0451-y"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.449"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192885"},{"key":"e_1_2_5_22_2","article-title":"Is there any correlation between decreased serum vascular endothelial growth factor (sVEGF) levels and nail toxicity in responsive metastatic breast cancer (MBC) patients treated with weekly docetaxel? 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