{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:28:40Z","timestamp":1789921720852,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The aim was to identify age\u2010 related and gender\u2010related differences in the clinical presentation and outcome of patients with primary cutaneous melanoma (CM).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 4785 CM patients without clinical evidence of metastasis diagnosed during the period 1976\u20132001 in southern Germany included in the analysis. Kaplan\u2010Meier analyses were performed to estimate and to compare disease\u2010specific survival (DSS) and survival after first recurrence (SAR). The Cox proportional hazards model was used to evaluate the effect of multiple variables on DSS and SAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Increasing age and male gender were independently associated with thicker tumors (&gt;2 mm) and histologic ulceration (<jats:italic>P<\/jats:italic> &lt; .001). Patients older than 65 years had lower 10\u2010year DSS than younger patients (81.8% vs 88.4%, <jats:italic>P<\/jats:italic> &lt; .001) and this difference was more pronounced in women (<jats:italic>P<\/jats:italic> &lt; .001) than in men (<jats:italic>P<\/jats:italic> = .06). Males had lower 10\u2010year DSS than females (83.5% vs 88.5%, <jats:italic>P<\/jats:italic> &lt; .001) but this difference did not reach statistical significance in patients older than 65 years (<jats:italic>P<\/jats:italic> = .162). In multivariate analysis adjusted for tumor thickness, ulceration, anatomic site, histologic subtype, DSS, site of first recurrence, time trend, sentinel lymph node status, age, and gender were independent predictors of DSS and SAR (<jats:italic>P<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Older age and male gender are associated with prognostically unfavorable primary CM. Expansion of current preventive strategies to target these subgroups is warranted. Moreover, age and gender are independent predictors of the outcome of CM patients. Females have a better prognosis than males but this difference disappears after the age of 65. Younger patients have a more favorable prognosis than older patients, a difference more pronounced in women. 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