{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:58Z","timestamp":1791125638967,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This analysis included 272 5\u2010year AML survivors who participated in the Childhood Cancer Survivor Study (CCSS). All patients were diagnosed at age \u226421 years between the years 1970 and 1986, and none underwent stem cell transplantation. Rates of survival, relapse, and late outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The average follow\u2010up was 20.5 years (range, 5\u201333 years). The overall survival rate was 97% at 10 years (95% confidence interval [95%CI], 94%\u201398%) and 94% at 20 years (95% CI, 90%\u201396%). Six survivors reported 8 recurrences. The cumulative incidence of recurrent AML was 6.6% at 10 years (95% CI, 3.7%\u20139.6%) and 8.6% at 20 years (95% CI, 5.1%\u201312.1%). Ten subsequent malignant neoplasms (SMN) were reported, including 4 with a history of radiation therapy, for a 20\u2010year cumulative incidence of 1.7% (95% CI, 0.02%\u20133.4%). Six cardiac events were reported, for a 20\u2010year cumulative incidence 4.7% (95% CI, 2.1%\u20137.3%). Half of the survivors reported a chronic medical condition and, compared with siblings, were at increased risk for severe or life\u2010threatening chronic medical conditions (16% vs 5.8%; <jats:italic>P<\/jats:italic> &lt; .001). Among those aged \u226525 years, the age\u2010adjusted marriage rates were similar among survivors and the general United States population (57% for both) and lower compared with siblings (67%; <jats:italic>P<\/jats:italic> &lt; .01). Survivors' college graduation rates were lower compared with siblings but higher than the general population (40% vs 52% vs 34%, respectively; <jats:italic>P<\/jats:italic> &lt; .01). Employment rates were similar between survivors, siblings, and the general population (93%, 97.6%, and 95.8%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Long\u2010term survival from childhood AML \u22655\u2010years after diagnosis was favorable. Late\u2010occurring medical events remained a concern with socioeconomic achievement lower than expected within the individual family unit, although it was not different from the general United States population. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23405","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T18:46:27Z","timestamp":1204915587000},"page":"2071-2079","source":"Crossref","is-referenced-by-count":119,"title":["Twenty years of follow\u2010up among survivors of childhood and young adult acute myeloid leukemia"],"prefix":"10.1002","volume":"112","author":[{"given":"Daniel A.","family":"Mulrooney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Dover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Sklar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Childhood Cancer Survivor Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,21]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"SEER Cancer Statistics Review, 1975\u20132000","author":"Ries LAG","year":"2003"},{"key":"e_1_2_5_3_2","first-page":"1057","article-title":"What is the optimal therapy for childhood AML?","volume":"16","author":"Loeb DM","year":"2002","journal-title":"Oncology (Williston Park)."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170507"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.1.127"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.8.1448"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.538"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.56"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.016"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.18.3273"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(03)00142-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2238"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1316"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9"},{"key":"e_1_2_5_15_2","volume-title":"Statistical Models in Epidemiology","author":"Clayton D","year":"1993"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_5_19_2","unstructured":"U.S. Census Bureau Population Division Current Population Survey (CPS) Reports Annual Demographic Supplement: Children's Living Arrangements and Characteristics: March 2001. 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