{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:10:27Z","timestamp":1791382227856,"version":"4.3.3"},"reference-count":134,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T00:00:00Z","timestamp":1210550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchopulmonary neuroendocrine tumors (BP\u2010NETs) comprise \u224820% of all lung cancers and represent a spectrum of tumors arising from neuroendocrine cells of the BP\u2010epithelium. Although they share structural, morphological, immunohistochemical, and ultrastructural features, they are separated into 4 subgroups: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), large\u2010cell neuroendocrine carcinoma (LCNEC), and small\u2010cell lung carcinoma (SCLC), which exhibit considerably different biological characteristics. The clinical presentation includes cough, hemoptysis, and obstructive pneumonia but varies depending on site, size, and growth pattern. Less than 5% of BP\u2010NETs exhibit hormonally related symptoms such as carcinoid syndrome, Cushing, acromegaly, and SIADH. SCLC is the most common BP\u2010NET, while LCNEC is rare, \u224810% and \u22641%, respectively, of all lung cancers. Both SCLC and LCNEC progress rapidly, are aggressively metastatic, and exhibit a poor prognosis. The incidence of BP\u2010carcinoids (TC and AC) in the US was 1.57 of 100,000 in 2003 (an unexplained and substantial increase over the last 30 years, \u22486% per year). No curative treatment except for radical surgery (almost never feasible) exists. The slow\u2010growing TC exhibit a fairly good prognosis (\u224888%, 5\u2010year survival), whereas AC demonstrate a 5\u2010year survival of \u224850%, and the highly malignant LCNEC and SCLC5\u2010year survival of 15% to 57% and &lt;5%, respectively. This review provides a broad overview on BP\u2010NETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p>","DOI":"10.1002\/cncr.23542","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T16:16:32Z","timestamp":1210608992000},"page":"5-21","source":"Crossref","is-referenced-by-count":386,"title":["Bronchopulmonary neuroendocrine tumors"],"prefix":"10.1002","volume":"113","author":[{"given":"Bjorn I.","family":"Gustafsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max V.","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin M.","family":"Modlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,20]]},"reference":[{"key":"e_1_2_23_2_2","volume-title":"Traite de l'auscultation mediate et des maladies des poumons et du coeur","author":"Laennec R","year":"1831"},{"key":"e_1_2_23_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2007.01.004"},{"key":"e_1_2_23_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2005.01.001"},{"key":"e_1_2_23_5_2","volume-title":"Pathology and Genetics","author":"Travis W","year":"2004"},{"key":"e_1_2_23_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.122523"},{"key":"e_1_2_23_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.4859"},{"key":"e_1_2_23_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1647"},{"key":"e_1_2_23_9_2","unstructured":"The US National Cancer Institute. Surveillance Epidemiology and End Results (SEER) data base 1973\u20132004 http:\/\/seer.cancer.gov\/2007."},{"key":"e_1_2_23_10_2","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.52.Suppl_397"},{"key":"e_1_2_23_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092360121"},{"key":"e_1_2_23_12_2","first-page":"449","article-title":"Development of pulmonary neuroendocrine cells of fetal hamster in explant culture","volume":"77","author":"Ito T","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_23_13_2","doi-asserted-by":"publisher","DOI":"10.2350\/07-04-0267.1"},{"key":"e_1_2_23_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0479-2"},{"key":"e_1_2_23_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1160"},{"key":"e_1_2_23_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.11.878"},{"key":"e_1_2_23_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00267.2006"},{"key":"e_1_2_23_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90024-3"},{"key":"e_1_2_23_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00167.2005"},{"key":"e_1_2_23_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0126"},{"key":"e_1_2_23_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4374"},{"key":"e_1_2_23_22_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013071"},{"key":"e_1_2_23_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11105"},{"key":"e_1_2_23_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.03.007"},{"key":"e_1_2_23_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00080-6"},{"key":"e_1_2_23_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210293271806"},{"key":"e_1_2_23_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199508000-00013"},{"key":"e_1_2_23_28_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.7205\/MILMED.170.5.439","article-title":"The demonstration of pulmonary neuroendocrine cell hyperplasia with tumorlets in a patient with chronic cough and a history of multiple medical problems","volume":"170","author":"Carmichael MG","year":"2005","journal-title":"Mil Med"},{"key":"e_1_2_23_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60641-7"},{"key":"e_1_2_23_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)00630-P"},{"key":"e_1_2_23_31_2","first-page":"545","article-title":"Pulmonary neuroendocrine carcinomas. A review of 234 cases and a statistical analysis of 50 cases treated at 1 institution using a simple clinicopathologic classification","volume":"126","author":"Huang Q","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_23_32_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.19294"},{"key":"e_1_2_23_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.02.004"},{"key":"e_1_2_23_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/107327480601300404"},{"key":"e_1_2_23_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200209000-00009"},{"key":"e_1_2_23_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149690.75462.29"},{"key":"e_1_2_23_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31815bdc0d"},{"key":"e_1_2_23_38_2","volume-title":"Principles and Practice of Oncology","author":"Idhe D","year":"1997"},{"key":"e_1_2_23_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90428-2"},{"key":"e_1_2_23_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2"},{"key":"e_1_2_23_41_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100437"},{"key":"e_1_2_23_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64780-3"},{"key":"e_1_2_23_43_2","first-page":"4894","article-title":"Genome\u2010wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non\u2010small cell lung cancer, and loci clustering","volume":"60","author":"Girard L","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_23_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<600::AID-CNCR10>3.0.CO;2-W"},{"key":"e_1_2_23_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6274023"},{"key":"e_1_2_23_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/329451a0"},{"key":"e_1_2_23_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00337-8"},{"key":"e_1_2_23_48_2","first-page":"613","article-title":"Microsatellite alteration at chromosome 3p loci in neuroendocrine and non\u2010neuroendocrine lung tumors. Histogenetic and clinical relevance","volume":"149","author":"Hurr K","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_23_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1109::AID-CNCR9>3.0.CO;2-2"},{"key":"e_1_2_23_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2006.01985.x"},{"key":"e_1_2_23_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.13"},{"key":"e_1_2_23_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20825"},{"key":"e_1_2_23_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00372-6"},{"key":"e_1_2_23_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200005)28:1<58::AID-GCC7>3.0.CO;2-2"},{"key":"e_1_2_23_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.13.2285"},{"key":"e_1_2_23_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65653-2"},{"key":"e_1_2_23_57_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8070"},{"key":"e_1_2_23_58_2","first-page":"5797","article-title":"Infrequent mutations of the p53 gene in pulmonary carcinoid tumors","volume":"53","author":"Lohmann DR","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_23_59_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887616"},{"key":"e_1_2_23_60_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199206000-00006"},{"key":"e_1_2_23_61_2","first-page":"451","article-title":"Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small\u2010cell lung carcinoma","volume":"7","author":"Sameshima Y","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_23_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-200003000-00008"},{"key":"e_1_2_23_63_2","first-page":"149","article-title":"Genetic alteration in carcinoid tumors of the lung","volume":"9","author":"Sugio K","year":"2003","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"e_1_2_23_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2554494"},{"key":"e_1_2_23_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03212.x"},{"key":"e_1_2_23_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1590::AID-CNCR13>3.0.CO;2-C"},{"key":"e_1_2_23_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.COC.0000054894.64867.80"},{"key":"e_1_2_23_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1401"},{"key":"e_1_2_23_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006419"},{"key":"e_1_2_23_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20901"},{"key":"e_1_2_23_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)91139-Z"},{"key":"e_1_2_23_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(89)80201-X"},{"key":"e_1_2_23_73_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0022-5223(19)38842-7","article-title":"Bronchial carcinoids. Review of 124 cases","volume":"89","author":"McCaughan BC","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_23_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)62188-1"},{"key":"e_1_2_23_75_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.119886"},{"key":"e_1_2_23_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000159356.42064.48"},{"key":"e_1_2_23_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01795957"},{"key":"e_1_2_23_78_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-3-209"},{"key":"e_1_2_23_79_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2156"},{"key":"e_1_2_23_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90065-X"},{"key":"e_1_2_23_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04118-8"},{"key":"e_1_2_23_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20043"},{"key":"e_1_2_23_83_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2007.n.008"},{"issue":"2","key":"e_1_2_23_84_2","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1093\/annonc\/12.suppl_2.S69","article-title":"Clinical significance of blood chromogranin A measurement in neuroendocrine tumours","volume":"12","author":"Seregni E","year":"2001","journal-title":"Ann Oncol"},{"key":"e_1_2_23_85_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021405"},{"key":"e_1_2_23_86_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.1.1820087"},{"key":"e_1_2_23_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<577::AID-CNCR2820660328>3.0.CO;2-Y"},{"key":"e_1_2_23_88_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.156.1.1845787"},{"key":"e_1_2_23_89_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.163.3.8079844"},{"key":"e_1_2_23_90_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091528"},{"key":"e_1_2_23_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb17263.x"},{"key":"e_1_2_23_92_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01931.x"},{"key":"e_1_2_23_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0020-3"},{"key":"e_1_2_23_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.05.023"},{"key":"e_1_2_23_95_2","first-page":"224","article-title":"Somatostatin receptor scintigraphy in small\u2010cell lung cancer: results of a multicenter study","volume":"39","author":"Reisinger I","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_23_96_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035667"},{"key":"e_1_2_23_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0937-8"},{"key":"e_1_2_23_98_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1938"},{"key":"e_1_2_23_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1160-y"},{"key":"e_1_2_23_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70801-4"},{"key":"e_1_2_23_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2006.04.001"},{"key":"e_1_2_23_102_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/annonc\/mdl374","article-title":"A prospective study of PET\/CT in initial staging of small\u2010cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis","volume":"18","author":"Fischer B","year":"2007","journal-title":"Ann Oncol"},{"key":"e_1_2_23_103_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1_suppl.129S"},{"key":"e_1_2_23_104_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.14"},{"key":"e_1_2_23_105_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5223(94)70444-9","article-title":"Treatment and prognosis in bronchial carcinoids involving regional lymph nodes","volume":"107","author":"Martini N","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_23_106_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2006.08.006"},{"key":"e_1_2_23_107_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901283400403"},{"key":"e_1_2_23_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.041"},{"key":"e_1_2_23_109_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1405"},{"key":"e_1_2_23_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0355-4"},{"key":"e_1_2_23_111_2","first-page":"1599","article-title":"Effects of therapy with [177Lu\u2010DOTA0, Tyr3]octreotate in patients with paraganglioma, meningioma, small cell lung carcinoma, and melanoma","volume":"47","author":"van Essen M","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_23_112_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cco.0000208790.45312.25"},{"key":"e_1_2_23_113_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410703"},{"key":"e_1_2_23_114_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092718"},{"key":"e_1_2_23_115_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi365"},{"key":"e_1_2_23_116_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.108"},{"key":"e_1_2_23_117_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.17.186"},{"key":"e_1_2_23_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00055-6"},{"key":"e_1_2_23_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00230-8"},{"key":"e_1_2_23_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21389"},{"key":"e_1_2_23_121_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000106"},{"key":"e_1_2_23_122_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199808000-00003"},{"key":"e_1_2_23_123_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017439009098055"},{"key":"e_1_2_23_124_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9234-x"},{"key":"e_1_2_23_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050055"},{"key":"e_1_2_23_126_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/90.6.641"},{"key":"e_1_2_23_127_2","first-page":"39","article-title":"Coexpression of neuroendocrine markers and epithelial cytoskeletal proteins in bronchopulmonary neuroendocrine neoplasms","volume":"52","author":"Blobel GA","year":"1985","journal-title":"Lab Invest"},{"key":"e_1_2_23_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(00)00248-8"},{"key":"e_1_2_23_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80008-3"},{"key":"e_1_2_23_130_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00198.x"},{"key":"e_1_2_23_131_2","first-page":"6068","article-title":"A comparison of synaptophysin, chromogranin, and L\u2010dopa decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines","volume":"50","author":"Jensen SM","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_23_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600272"},{"key":"e_1_2_23_133_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199106000-00003"},{"key":"e_1_2_23_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.09.070"},{"key":"e_1_2_23_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010601)91:11<1992::AID-CNCR1224>3.0.CO;2-5"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.23542","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.23542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:39:11Z","timestamp":1760305151000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.23542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,20]]},"references-count":134,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/cncr.23542"],"URL":"https:\/\/doi.org\/10.1002\/cncr.23542","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,20]]}}}