{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:18:51Z","timestamp":1791778731921,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T00:00:00Z","timestamp":1210550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>Because of scarce data from larger series and nonhomogeneous selection criteria, further information is needed on peritonectomy with hyperthermic intraperitoneal chemotherapy (HIPEC) in managing patients with ovarian peritoneal carcinomatosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>In an open, prospective, single\u2010center nonrandomized phase 2 study conducted from November 2000 to April 2007, 47 patients with primary advanced or recurrent ovarian cancer and diffuse peritoneal carcinomatosis were enrolled; 22 underwent primary and 25 secondary cytoreduction plus immediate HIPEC followed by systemic chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>The overall mean Sugarbaker peritoneal cancer index was 14.9 (range, 6\u201328). A mean of 6 surgical procedures were required per patient (range, 4\u201310). In 87.3% of the patients debulking achieved optimal cytoreduction (Sugarbaker completeness of cytoreduction [CC] score 0\u20131), whereas in 12.7% it left macroscopic residual disease (CC\u20102 or CC\u20103). Major complications developed in 21.3% of the patients and the in\u2010hospital mortality rate was 4.2%. The mean overall survival was 30.4 months, median survival was 24 months, and mean disease\u2010free survival was 27.4 months. Five\u2010year survival was 16.7%. Univariate (log\u2010rank test and analysis of variance) and multivariate analyses (Cox proportional\u2010hazard model) identified the CC score as the main factor capable of independently influencing survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>Peritonectomy procedures combined with HIPEC offer promising long\u2010term survival in patients with diffuse peritoneal ovarian carcinomatosis. They achieve high adequate primary and secondary surgical cytoreduction rates with acceptable morbidity and mortality. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.23553","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T16:16:28Z","timestamp":1210608988000},"page":"315-325","source":"Crossref","is-referenced-by-count":206,"title":["Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer"],"prefix":"10.1002","volume":"113","author":[{"given":"Angelo","family":"Di 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