{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:54:45Z","timestamp":1763016885391,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T00:00:00Z","timestamp":1222905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>Limited data exist about the role of second\u2010line chemotherapy response assessed by positron emission tomography (PET) as a prognostic factor in patients with aggressive non\u2010Hodgkin Lymphoma (NHL) who undergo autologous stem cell transplantation (ASCT). The objective of this analysis was to investigate the main determinants of prognosis in patients with aggressive B\u2010cell NHL who undergo ASCT, focusing on the impact of pretransplantation PET, secondary age\u2010adjusted International Prognostic Index (sAA\u2010IPI) score, histology, and previous response to first\u2010line chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Seventy\u2010five patients with diffuse, large B\u2010cell lymphoma or grade 3 follicular lymphoma who were treated at the author' institution with second\u2010line chemotherapy (combined ifosfamide, etoposide, and epirubicin [IEV]) followed by ASCT between September 2002 and September 2006 were included. All patients were evaluated by PET after 1 to 3 courses of IEV chemotherapy before ASCT, and all patients received a conditioning regimen of combined carmustine, etoposide, cytosine arabinoside, and melphalan. The prognostic impact of pretransplantation PET, sAA\u2010IPI score, histology, and previous response to first\u2010line chemotherapy was evaluated by univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Seventy\u2010two of 75 patients underwent ASCT. In a univariate analysis for progression\u2010free survival (PFS) and overall survival (OS), a significant association was observed with pretransplantation PET (PFS, <jats:italic>P<\/jats:italic> &lt; .00001; OS, <jats:italic>P<\/jats:italic> &lt; .01) and previous first\u2010line response (PFS, <jats:italic>P<\/jats:italic> = .02; OS, <jats:italic>P<\/jats:italic> = .04). In the multivariate framework, pretransplantation PET was identified as the only independent prognostic factor (PFS, <jats:italic>P<\/jats:italic> &lt; .001; OS, <jats:italic>P<\/jats:italic> = .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>The current data indicated that pretransplantation PET is the main prognostic predictor in patients with aggressive B\u2010cell NHL who are scheduled for ASCT. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23861","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T11:55:50Z","timestamp":1222948550000},"page":"2496-2503","source":"Crossref","is-referenced-by-count":61,"title":["Pretransplantation positron emission tomography scan is the main predictor of autologous stem cell transplantation outcome in aggressive B\u2010cell non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"113","author":[{"given":"Enrico","family":"Derenzini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Musuraca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Fanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Stefoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lapo","family":"Alinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Gandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Baccarani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Luigi","family":"Zinzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281409"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332305"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.10.1846"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3837"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008327127033"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1182\/blood.V94.2.429","article-title":"Whole\u2010body positron emission tomography 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