{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:19:35Z","timestamp":1790039975926,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:00:00Z","timestamp":1222992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been previously reported. These results extend those provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program in their detail and interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>Survival trends of primary cancers in children and adolescents (ages birth to 19 years) were evaluated using SEER 9 data. Five\u2010year and 10\u2010year relative survival rates across 5\u2010year (1975\u20101979, 1985\u20101989, and 1995\u20101999) and 10\u2010year (1975\u20101984 and 1985\u20101994) cohorts were compared via Z\u2010tests. Annual percent change (APC) in survival was computed via weighted least\u2010squares regression. Rates in Hispanic children and adolescents were compared with those in non\u2010Hispanic whites and blacks (SEER 13, 1995\u20101999).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>\n                      Five\u2010year survival rates increased significantly overall (1975\u20101979: 63% vs 1995\u20101999: 79%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and for nearly all histologic types examined; increases were greatest for ependymoma (+37%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and non\u2010Hodgkin lymphoma (+34%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001). Hispanic children and adolescents had somewhat poorer 5\u2010year rates than non\u2010Hispanic whites overall (74% vs 81%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and for Ewing sarcoma, leukemia, central nervous system tumors, and melanoma. Ten\u2010year rates also increased significantly overall (1975\u20101984: 61% vs 1985\u20101994: 72%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and for a majority of cancer types. The largest improvements were noted for acute lymphoblastic leukemia (+19%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and non\u2010Hodgkin lymphoma (+19%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>Observed trends reinforce the need for resources devoted to advancing treatment modalities, reducing disparities among racial\/ethnic groups and adolescents, and providing long\u2010term care of survivors. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.23866","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T21:08:16Z","timestamp":1223068096000},"page":"2575-2596","source":"Crossref","is-referenced-by-count":221,"title":["Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975\u20101999"],"prefix":"10.1002","volume":"113","author":[{"given":"Amy M.","family":"Linabery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"10 Leading Causes of Deaths, United States, 2004, All Races, Both Sexes, Ages: 1\u201019","author":"WISQARS","year":"2007"},{"key":"e_1_2_5_3_2","volume-title":"Cancer Facts and Figures 2007","author":"American Cancer Society","year":"2007"},{"key":"e_1_2_5_4_2","volume-title":"Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975\u20101995. 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