{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:10:11Z","timestamp":1792195811127,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T00:00:00Z","timestamp":1224201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND.<\/jats:title>\n                    <jats:p>The purpose of the current study was to determine the prevalence of low bone mineral density (BMD) (ie, osteopenia) and identify factors associated with low BMD in young adult survivors of childhood acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS.<\/jats:title>\n                    <jats:p>Dual energy x\u2010ray absorptiometry was used to evaluate BMD in 74 randomly selected, long\u2010term childhood ALL survivors initially treated in Minneapolis\/St. Paul, Minnesota. Growth hormone (GH)\u2010releasing hormone\u2013arginine stimulation testing was conducted to evaluate peak GH level, and insulin\u2010like growth factor I (IGF\u2010I) and other markers of endocrine functioning were also evaluated in relation to BMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS.<\/jats:title>\n                    <jats:p>\n                      The mean age at the time of interview was 30 years, and the mean time since diagnosis was 24 years. Low BMD (Z\u2010score, \u2264\u22121) was present in 24% of subjects, including 1 with osteoporosis. Low BMD was substantially more prevalent in men than in women and was strongly associated with short height. The mean height Z\u2010score for those with low BMD was \u22121.44, compared with a height Z\u2010score of \u22120.39 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .01) for those with normal BMD. GH insufficiency, low IGF\u2010I Z\u2010score, and current smoking were also suggestive risk factors for low BMD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS.<\/jats:title>\n                    <jats:p>In this long\u2010term follow\u2010up study of childhood ALL survivors, low BMD was found to be more prevalent than expected based on population normative data, specifically in men. The health consequences of early\u2010onset BMD problems in childhood ALL survivors need to be carefully monitored. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.23912","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T19:52:15Z","timestamp":1224273135000},"page":"3248-3256","source":"Crossref","is-referenced-by-count":60,"title":["Bone mineral density in young adult survivors of acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"113","author":[{"given":"Inas H.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Dengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Scott","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Gurney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.047"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960801)78:3<532::AID-CNCR22>3.0.CO;2-Z"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199805000-00009"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70349-7"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00654.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.113102"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:5:2:167"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1998)78:11 <35::AID-IJC11>3.0.CO;2-I"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199806)30:6<347::AID-MPO8>3.0.CO;2-E"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3441"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1570225"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22546"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100608"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00438.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80536-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10338"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050918"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00169-7"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199904)32:4<272::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.12.2010"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7897"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.1.55"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092410409"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199710)249:2<163::AID-AR2>3.0.CO;2-Z"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090822"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.3.669"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.8.3624"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22120"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1316"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8509"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:15:1:029"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0126"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.091"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071871"},{"key":"e_1_2_5_36_2","unstructured":"ARUP Laboratories. National reference laboratory test directory [monograph online]. Available at:http:\/\/www.aruplab.com\/guides\/ug\/tests\/0070125.jspAccessed April 30 2008."},{"key":"e_1_2_5_37_2","unstructured":"Esoterix Laboratory Services Inc. Expected values and S.I. Unit conversion pocket book [monograph online]. Available at:http:\/\/www.esoterix.com\/files\/expected_values.pdfAccessed April 29 2008."},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0124"},{"key":"e_1_2_5_39_2","volume-title":"Anthropometric Reference Data for Children and Adults: U.S. Population, 1999\u20102002","author":"McDowell MA","year":"2005"},{"key":"e_1_2_5_40_2","volume-title":"Advance data from vital and health statistics; no 361","author":"McDowell MA","year":"2005"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1998)78:11 <40::AID-IJC12>3.0.CO;2-H"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(20001001)35:4<415::AID-MPO4>3.0.CO;2-9"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00381-1"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.11.1769"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.6.1073"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402078"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00124-5"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.02.022"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920030-00002"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.01.003"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(95)00036-A"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00147-1"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8417"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13276.x"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100812"},{"key":"e_1_2_5_56_2","series-title":"Pediatric Endocrinology","first-page":"65","author":"Rosenbloom A","year":"2007"},{"key":"e_1_2_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70020-X"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053301"},{"key":"e_1_2_5_59_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2007.02.007"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070204"},{"key":"e_1_2_5_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03120.x"},{"key":"e_1_2_5_62_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.2.215"},{"key":"e_1_2_5_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7112.841"},{"key":"e_1_2_5_64_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.23912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.23912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:13:04Z","timestamp":1760296384000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.23912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,17]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1002\/cncr.23912"],"URL":"https:\/\/doi.org\/10.1002\/cncr.23912","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,17]]}}}