{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:15:10Z","timestamp":1791130510160,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:00:00Z","timestamp":1224028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p>2\u2010Fluoro\u20102\u2010deoxy\u2010D\u2010glucose (FDG) imaging is highly accurate for assessing solitary pulmonary nodules (SPNs) in patients without known malignancy. In the current study, the authors evaluated FDG\u2010positron emission tomography\/computed tomography (PET\/CT) for the characterization of SPN in cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>FDG\u2010PET\/CT was performed in 56 cancer patients to evaluate SPNs that measured 15 \u00b1 8 mm in greatest dimension. The diagnosis was confirmed by histology (n = 34 patients), or by CT or clinical follow\u2010up (n = 22 patients). The performance of PET\/CT was calculated for visual and semiquantitative assessment and was related to SPN size, location, histology, and time after initial cancer diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p>Malignancy was diagnosed in 27 of 56 SPNs (48%; 18 second primary tumors and 9 metastases). There were 26 true\u2010positive PET\/CT studies (17 second primaries and 9 metastases), 5 false\u2010positive studies, 24 true\u2010negative studies, and 1 false\u2010negative study. The sensitivity of PET\/CT for diagnosing malignant SPN in patients with cancer was significantly greater for visual analysis than for semiquantitative analysis (96% vs 89%, respectively; <jats:italic>P<\/jats:italic> &lt; .05). Specificity and accuracy were similar for both methods (83% and 89% vs 93% and 91%, respectively). The presence of low\u2010intensity FDG uptake increased the detection rate of malignancy from 4% in non\u2010FDG\u2013avid SPNs to 40%, mainly in second primary tumors. False\u2010positive results were more frequent with lower than mediastinal uptake versus higher than mediastinal uptake (3 of 5 SPNs vs 2 of 26 SPNs, respectively; <jats:italic>P<\/jats:italic> &lt; .01) and in SPNs &gt;10 mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>FDG imaging was highly accurate for the diagnosis of malignant SPNs in patients with cancer, similar to the general population. The presence of any FDG avidity had significantly greater sensitivity than semiquantitative analysis. The current results indicated that lower than mediastinal uptake should be explored cautiously, particularly for second primary tumors, whereas no FDG avidity was a better predictor of SPN benignity than very low uptake. Cancer 2008. \u00a9 2008 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.23928","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T21:28:12Z","timestamp":1224106092000},"page":"3213-3221","source":"Crossref","is-referenced-by-count":33,"title":["Noninvasive diagnosis of solitary pulmonary lesions in cancer patients based on 2\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose avidity on positron emission tomography\/computed tomography"],"prefix":"10.1002","volume":"113","author":[{"given":"Rachel","family":"Bar\u2010Shalom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Guralnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.2.416"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.1075"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590100563"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.7.914"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2490"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200606000-00006"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2391050343"},{"key":"e_1_2_5_9_2","first-page":"443","article-title":"Tissue characterization of solitary pulmonary nodule: comparative study between helical dynamic CT and integrated PET\/CT","volume":"47","author":"Yi CA","year":"2006","journal-title":"J Nucl Med."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.03.095"},{"key":"e_1_2_5_11_2","first-page":"214","article-title":"Accuracy of PET\/CT in characterization of solitary pulmonary lesions","volume":"48","author":"Kim SK","year":"2007","journal-title":"JNucl Med."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.6.2175"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.4.982"},{"key":"e_1_2_5_14_2","first-page":"15","article-title":"Clinical significance of small pulmonary nodules with little or no 18F\u2010FDG uptake on PET\/CT images of patients with nonthoracic malignancies","volume":"48","author":"O JH","year":"2007","journal-title":"J Nucl Med."},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.044990"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.07.072"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0924-0"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1552-7"},{"key":"e_1_2_5_19_2","first-page":"426","article-title":"Accuracy of PET for diagnosis of solid pulmonary lesions with 18F\u2010FDG uptake below the standardized uptake value of 2.5","volume":"47","author":"Hashimoto Y","year":"2006","journal-title":"J Nucl Med."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2372041887"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.1.r00oc20257"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.23928","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.23928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:13:36Z","timestamp":1760296416000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.23928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,15]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1002\/cncr.23928"],"URL":"https:\/\/doi.org\/10.1002\/cncr.23928","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,15]]}}}