{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:47:12Z","timestamp":1761155232902,"version":"build-2065373602"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Cytology and core\u2010needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory. In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benign. The authors of this report evaluated the impact of the screen\u2010detected BBL at risk of developing cancer that were counted in the quota of benign breast open biopsies in the Breast Cancer Screening Program of Verona.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Benign open biopsies were subdivided into 4 groups according to their risk of developing cancer: Histo1, normal histology; Histo2, \u2018pure\u2019 BBL (fibroadenoma, fibrocystic disease, mastitis, adenosis); Histo3, BBL with a low risk of developing cancer (radial scar, papilloma, papillomatosis, phyllodes tumor, mucocele\u2010like lesion); and Histo4, BBL with a high risk of developing cancer (atypical columnar cell hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 510 open biopsies, 83 biopsies were benign, and the ratio of benign to malignant biopsies was 1:5. Histo1 was observed in 4.8% of all benign open biopsies, Histo2 was observed in 37.4%, Histo3 was observed in 31.3%, and Histo4 was observed 26.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>BBL at risk of developing cancer may be numerous in screening programs. It is inappropriate to include BBL at risk of developing cancer in the overall benign open biopsy rate. The authors propose separating pure BBL from lesions at higher risk of developing cancer. To date, there is no evidence to support the premise that detecting high\u2010risk proliferative lesions leads to benefits in terms of reduced mortality; however, these lesions need to be counted separately for future evaluations. Cancer 2009. \u00a9 2008 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24038","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T18:29:30Z","timestamp":1230748170000},"page":"499-507","source":"Crossref","is-referenced-by-count":17,"title":["Benign breast lesions at risk of developing cancer\u2014A challenging problem in breast cancer screening programs"],"prefix":"10.1002","volume":"115","author":[{"given":"Erminia","family":"Manfrin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Mariotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Remo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Reghellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Falsirollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Dalfior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bricolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Piazzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Bonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194502000-00009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.5.1111"},{"key":"e_1_2_6_4_2","first-page":"231","article-title":"An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions","volume":"55","author":"Wellings SR","year":"1975","journal-title":"J Natl Cancer Inst."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820215)49:4<751::AID-CNCR2820490426>3.0.CO;2-Y"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120303"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910470513"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480070057030"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930615)71:12<3896::AID-CNCR2820711217>3.0.CO;2-I"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70435-7"},{"key":"e_1_2_6_12_2","first-page":"1053","article-title":"Benign breast changes and the risk for subsequent breast cancer: an update of the 1985 consensus statement. Cancer Committee of the College of American Pathologists","volume":"122","author":"Fitzgibbons PL","year":"1998","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_6_13_2","first-page":"1048","article-title":"Benign breast diseases and premalignant breast disease","volume":"122","author":"Page DL","year":"1998","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0080047"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200204000-00003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200306000-00017"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2004.03.013"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044383"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.164.5.7717215"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303575"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.5.1751341"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/0031302021000009315"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200209000-00001"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr625"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000152566.78066.d1"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.2.133"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01582.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0151"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9289-6"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22435"},{"volume-title":"European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis","year":"2006","author":"Perry N","key":"e_1_2_6_31_2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)82874-0"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)83481-6"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/jms.9.2.83"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/030089160409000602","article-title":"Benign breast diseases in breast cancer screening programs in Italy (2000\u20132001)","volume":"90","author":"Fabbri S","year":"2004","journal-title":"Tumori."},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0142-8"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23412"},{"volume-title":"World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Breast and Female Genital Organs","year":"2003","author":"Tavassoli FA","key":"e_1_2_6_38_2"},{"key":"e_1_2_6_39_2","first-page":"20","volume-title":"Six National Surveys on Italian Screening Programs","author":"Giorgi D","year":"2005"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00451-7"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1309\/0GYV4F2LLJAV4GFN"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1309\/61HM-89TD-0M3L-JAHH"},{"key":"e_1_2_6_43_2","first-page":"67","volume-title":"Rosen's Breast Pathology","author":"Rosen PP","year":"1997"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02898.x"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb01194.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9569-9"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02893.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198607000-00003"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-535.x"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.046227"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200305000-00001"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02890.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00328.x"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604296"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.24038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.24038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:10:35Z","timestamp":1760299835000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.24038"}},"subtitle":["Five years' experience of the Breast Cancer Screening Program in Verona (1999\u20102004)"],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/cncr.24038"],"URL":"https:\/\/doi.org\/10.1002\/cncr.24038","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}