{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:57:00Z","timestamp":1763726220116,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Bisphosphonate\u2010associated osteonecrosis of the jaws (BP\u2010ONJ) is a relatively new disease. The aim of this study was to evaluate the prevalence of BP\u2010ONJ in breast cancer patients with osseous metastasis and bisphosphonate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A retrospective study was conducted in a EUSOMA accredited breast unit in Germany. All patients treated from January of 2000 to March of 2006 with metastatic breast cancer and bisphosphonate therapy were reviewed. All patients were contacted, and missing data were completed through structured interviews with their dentists and physicians (n = 75). Primary outcome was the development of BP\u2010ONJ and the detection of possible additional trigger factors for the development of BP\u2010ONJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 117 patients with breast cancer fulfilled the inclusion criteria, and data for 75 still living patients were included. Of these 75, 4 patients developed a BP\u2010ONJ, resulting in a prevalence of 5.3%: 3 patients received zoledronate only; 1 patient had first pamidronate followed by zoledronate and ibandronate. A tooth extraction could be identified as an additional trigger factor for 2 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>With a prevalence of 5.3%, BP\u2010ONJ in breast cancer patients has become a relevant disease that should be discussed with patients for whom bisphosphonates have been recommended. Appropriate dental care before bisphosphonate therapy commences has been advised to reduce the occurrence of BP\u2010ONJ. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24119","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T16:10:58Z","timestamp":1232467858000},"page":"1631-1637","source":"Crossref","is-referenced-by-count":60,"title":["Incidence of bisphosphonate\u2010associated osteonecrosis of the jaws in breast cancer patients"],"prefix":"10.1002","volume":"115","author":[{"given":"Christian","family":"Walter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Al\u2010Nawas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"du Bois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Buch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Harter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut A.","family":"Gr\u00f6tz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003474.pub2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.2000.0210"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41388-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000615)88:12 <2961::AID-CNCR12>3.0.CO;2-L"},{"key":"e_1_2_6_6_2","first-page":"475","article-title":"Adverse effects of bisphosphonates: current issues","volume":"5","author":"Diel IJ","year":"2007","journal-title":"J Support Oncol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0120-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.09.001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-007-1666-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.4.613"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.2.193"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.05.041"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601101"},{"key":"e_1_2_6_16_2","first-page":"10","article-title":"Zahnarztliche Betreuung von Patienten unter\/nach Bisphosphonat\u2010Medikation","volume":"60","author":"Grotz KA","year":"2006","journal-title":"DZZ"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.070"},{"key":"e_1_2_6_18_2","first-page":"509","article-title":"Zahnarztliche Betreuung von Patienten mit tumortherapeutischer Kopf\u2010Hals\u2010Bestrahlung","volume":"57","author":"Grotz KA","year":"2002","journal-title":"DZZ"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200507073530120"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.03.006"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl408"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl163"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318074d363"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn164"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(88)90015-7"},{"key":"e_1_2_6_27_2","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone\u2010stimulated vascular regrowth in the ventral prostate in castrated rats","volume":"62","author":"Fournier P","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_28_2","unstructured":"Saarland Ministerium fur Justiz Gus.40 Jahre epidemiologisches Krebsregister Saarland 1967\u20102007 Dokumentieren Informieren Evaluieren2007. 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