{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:32:21Z","timestamp":1789162341915,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T00:00:00Z","timestamp":1232668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>It has been demonstrated that the tumor proliferation index has prognostic significance in patients with mantle cell lymphoma (MCL). Patients in most of studies, however, have been treated with relatively traditional chemotherapy regimens. At the authors' institution, patients with MCL received an aggressive chemotherapy regimen: rituximab plus hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with rituximab plus high\u2010dose methotrexate and cytarabine (R\u2010hyper\u2010CVAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors assessed the proliferation rate of MCL using immunohistochemistry and an antibody specific for Ki\u201067 in 71 untreated patients who subsequently received R\u2010hyper\u2010CVAD. The study group included 59 patients who had classic MCL and 12 patients who had the blastoid variant of MCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>For the entire study group and for the group of patients with classic MCL, a proliferation index of &gt;20% Ki\u201067\u2010positive cells was correlated significantly with shorter failure\u2010free survival. There was no correlation between the proliferation index and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results indicated that the proliferation index in patients with MCL predicted prognosis in those who uniformly received the R\u2010hyper\u2010CVAD chemotherapy regimen. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24141","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T15:46:18Z","timestamp":1232725578000},"page":"1041-1048","source":"Crossref","is-referenced-by-count":24,"title":["Proliferation predicts failure\u2010free survival in mantle cell lymphoma patients treated with rituximab plus hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with rituximab plus high\u2010dose methotrexate and cytarabine"],"prefix":"10.1002","volume":"115","author":[{"given":"Mar","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Romaguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar V.","family":"Inamdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Z.","family":"Rassidakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,23]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"168","volume-title":"World Health Organization Classification of Tumours. 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