{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:41:01Z","timestamp":1760298061318,"version":"build-2065373602"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T00:00:00Z","timestamp":1236729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Although the pathogenesis of Hodgkin disease (HD) remains unknown, the results of epidemiologic studies suggest that heritable factors are important in terms of susceptibility. Polymorphisms in DNA repair genes may contribute to individual susceptibility for development of different cancers. However, to the authors' knowledge, few studies to date have investigated the role of such polymorphisms as risk factors for development of HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors evaluated the relation between polymorphisms in 3 nucleotide excision repair pathway genes (XPD [Lys751Gln], XPC [Lys939Gln], and XPG [Asp1104His]), the base excision repair XRCC1 (Arg399Gln), and double\u2010strand break repair XRCC3 (Thr241Met) in a population of 200 HD cases and 220 matched controls. Variants were investigated independently and in combination; odd ratios (OR) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A positive association was found for XRCC1 gene polymorphism Arg399Gln (OR, 1.77; 95% confidence interval [95% CI], 1.16\u20102.71) and risk of HD. The combined analysis demonstrated that XRCC1\/XRCC3 and XRCC1\/XPC polymorphisms were associated with a significant increase in HD risk. XRCC1 Arg\/Arg and XRCC3 Thr\/Met genotypes combined were associated with an OR of 2.38 (95% CI, 1.24\u20104.55). The XRCC1 Arg\/Gln and XRCC3 Thr\/Thr, Thr\/Met, and Met\/Met genotypes had ORs of 1.88 (95% CI, 1.02\u20104.10), 1.97 (95% CI, 1.05\u20103.73), and 4.13 (95% CI, 1.50\u201011.33), respectively. XRCC1 Gln\/Gln and XRCC3 Thr\/Thr variant led to a significant increase in risk, with ORs of 3.00 (95% CI, 1.15\u20107.80). Similarly, XRCC1 Arg\/Gln together with XPC Lys\/Lys was found to significantly increase the risk of HD (OR, 2.14; 95% CI, 1.09\u20104.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>These data suggest that genetic polymorphisms in DNA repair genes may modify the risk of HD, especially when interactions between the pathways are considered. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24205","type":"journal-article","created":{"date-parts":[[2009,3,11]],"date-time":"2009-03-11T10:48:07Z","timestamp":1236768487000},"page":"1651-1659","source":"Crossref","is-referenced-by-count":29,"title":["Genetic polymorphisms in DNA repair genes as modulators of Hodgkin disease risk"],"prefix":"10.1002","volume":"115","author":[{"given":"Randa","family":"El\u2010Zein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia M.","family":"Monroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol J.","family":"Etzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea C.","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda L.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara S.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"volume-title":"Cancer Facts and Figures 2008, American Cancer Society","year":"2008","author":"American Cancer Society","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930801)72:3 <991::AID-CNCR2820721307>3.0.CO;2-5"},{"key":"e_1_2_6_4_2","first-page":"4103","article-title":"Reduced DNA repair capacity in lung cancer patients","volume":"56","author":"Wei Q","year":"1996","journal-title":"Cancer Res."},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/clinchem\/41.12.1848","article-title":"Variability in DNA repair and individual susceptibility to genotoxins","volume":"41","author":"Kyrtopoulos SA","year":"1995","journal-title":"Clin Chem."},{"key":"e_1_2_6_6_2","first-page":"3975","article-title":"Benzo(a)pyrene diol epoxide\u2010induced chromosomal aberrations and risk of lung cancer","volume":"56","author":"Wei Q","year":"1996","journal-title":"Cancer Res."},{"key":"e_1_2_6_7_2","first-page":"687","article-title":"Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer","volume":"6","author":"Spitz MR","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(96)90082-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910640105"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540412"},{"key":"e_1_2_6_11_2","first-page":"604","article-title":"Non\u2010conservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans","volume":"58","author":"Shen MR","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.11.874"},{"key":"e_1_2_6_13_2","first-page":"77","article-title":"Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma","volume":"8","author":"Dybdahl M","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4639-00294"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2006.10.003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj189"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-0094-9"},{"key":"e_1_2_6_18_2","first-page":"3321","article-title":"An intronic Poly(AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case\u2010control study","volume":"61","author":"Shen H","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh058"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.11.016"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0583"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11324"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm273"},{"key":"e_1_2_6_24_2","first-page":"2453","article-title":"Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia","volume":"27","author":"Deligezer U","year":"2007","journal-title":"Anticancer Res."},{"key":"e_1_2_6_25_2","first-page":"97","article-title":"Association of gene polymorphisms in the DNA repair gene XPD with risk of non\u2010Hodgkin's lymphoma","volume":"16","author":"Song B","year":"2008","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi."},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20520"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg120"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/321276"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2005.11.036"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh264"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/35094000"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.04.004"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.9.1437"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1433"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/509704"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-026690"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0177-2"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl013"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.22.4387"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01056.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/12347"},{"key":"e_1_2_6_42_2","first-page":"2557","article-title":"XRCC1 polymorphisms: effects on aflatoxin B1\u2010DNA adducts and glycophorin A variant frequency","volume":"59","author":"Lunn RM","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00532-2"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00030-1"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi002701e"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.8.2556-2563.2002"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00436.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1390"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i42.6593"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20210"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5389-5395.2005"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600667721"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.09.028"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.03.012"},{"key":"e_1_2_6_55_2","first-page":"1142","article-title":"DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma","volume":"11","author":"Duan Z","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.09.003"},{"key":"e_1_2_6_57_2","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1158\/1055-9965.1788.13.11","article-title":"Poly (AT) polymorphism in intron 11 of the XPC DNA repair gene enhances the risk of lung cancer","volume":"13","author":"Marin MS","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi115"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-162"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.03.010"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk153"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22588"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.24205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.24205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:11:59Z","timestamp":1760274719000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.24205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,6]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,4,15]]}},"alternative-id":["10.1002\/cncr.24205"],"URL":"https:\/\/doi.org\/10.1002\/cncr.24205","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2009,4,6]]}}}