{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:50:57Z","timestamp":1762505457835,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T00:00:00Z","timestamp":1238025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this study was to clarify the usefulness of positron emission tomography (PET) using<jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) and carbon 11\u2010labeled acetate (AC) for predicting the histologic types and tumor invasiveness of thymoma in a multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Forty thymomas were examined using both FDG\u2010PET and AC\u2010PET before surgery. The histologic types were type A in 1 thymoma, type AB in 12 thymomas, type B1 in 11 thymomas, type B2 in 7 thymomas, type B3 in 6 thymomas, and type C in 3 thymomas. Tumor invasiveness was assessed by pathologic tumor stage and was identified as stage I in 17 tumors, stage II in 17 tumors, stage III in 4 tumors, and stage IV in 2 tumors. FDG and AC uptake was measured as the maximum standard uptake value (SUV).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The FDG\u2010SUV in type C thymomas was significantly higher than that in the other types (A\u2010B3; <jats:italic>P<\/jats:italic> = .001 \u2013 <jats:italic>P<\/jats:italic> = .048). The AC\u2010SUV in type A\/AB thymomas was significantly higher than that in the other tumor types (B1\u2010C; <jats:italic>P<\/jats:italic> &lt; .001 \u2013 <jats:italic>P<\/jats:italic> = .002). All 3 type C tumors had an FDG\u2010SUV \u22656.3, and all 13 type A\/AB tumors had an FDG\u2010SUV &lt;6.3 and an AC\u2010SUV \u22655.7. All 17 thymomas that had an FDG\u2010SUV &lt;6.3 and an AC\u2010SUV &lt;5.7 were type B1, B2, or B3. Neither the FDG\u2010SUV nor the AC\u2010SUV differed significantly between the stages I\/II tumors and stage III\/IV tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Although neither the FDG\u2010SUV nor the AC\u2010SUV can predict the invasiveness of thymomas assessed by tumor stage, they are useful for predicting histologic types of thymoma. Thymomas with an FDG\u2010SUV &lt;6.3 and an AC\u2010SUV \u22655.7 almost certainly are types A\/AB, which is of considerable prognostic and management significance. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24278","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T15:09:27Z","timestamp":1238080167000},"page":"2531-2538","source":"Crossref","is-referenced-by-count":36,"title":["<sup>18<\/sup>F\u2010fluorodeoxyglucose and <sup>11<\/sup>C\u2010acetate positron emission tomography are useful modalities for diagnosing the histologic type of thymoma"],"prefix":"10.1002","volume":"115","author":[{"given":"Hidekatsu","family":"Shibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nomori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiichi","family":"Uno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Iyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Tomiyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Goya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Horio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"278","article-title":"Lung cancer proliferation correlates with [F\u201018] fluorodeoxyglucose positron emission tomography","volume":"124","author":"Vesselle H","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.03.020"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyl043"},{"volume-title":"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart","year":"2004","author":"Travis WD","key":"e_1_2_6_5_2"},{"key":"e_1_2_6_6_2","first-page":"1628","article-title":"18F\u2010FDG PET\/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups","volume":"47","author":"Sung YM","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_6_7_2","first-page":"1595","article-title":"Differential diagnosis of thymic tumors using a combination of 11C\u2010methionine PET and FDG PET","volume":"40","author":"Sasaki M","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.01.024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(77)90132-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb04380.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.3.687"},{"key":"e_1_2_6_12_2","first-page":"1957","article-title":"Relationship between myocardial clearance rates of carbon\u201011\u2010acetate\u2010deribed radiolabel and oxidative metabolism: physiologic basis and clinical significance","volume":"32","author":"Lear JL","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_6_13_2","first-page":"213","article-title":"C\u201011 acetate PET imaging in hepatocellular carcinoma and other liver masses","volume":"44","author":"Ho C","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_6_14_2","first-page":"181","article-title":"11C\u2010acetate PET imaging of prostate cancer","volume":"43","author":"Oyama N","year":"2002","journal-title":"J Nucl Med"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.06.003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.01.024"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199812000-00004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199612000-00006"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb02936.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(00)00195-5"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(80)90223-4"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.24278","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.24278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:11:41Z","timestamp":1760267501000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.24278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,20]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/cncr.24278"],"URL":"https:\/\/doi.org\/10.1002\/cncr.24278","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2009,5,20]]}}}