{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:36Z","timestamp":1786977516410,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A carboplatin\u2010based chemotherapy regimen was used as primary postoperative therapy in infants with central nervous system (CNS) tumors to limit renal and ototoxicity and to target systemic exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Fifty\u2010three patients aged &lt;age 3 years with embryonal CNS tumor medulloblastoma (n = 20), ependymoma (EP, n = 21), choroid plexus carcinoma (CPCA, n = 5), and primitive embryonal neoplasms including atypical teratoid rhabdoid tumors (n = 7) were treated with cyclophosphamide, etoposide, and carboplatin. Radiation therapy was used only for residual disease at the end of chemotherapy or disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The response rate after 2 cycles of chemotherapy was 34% (complete response, 13.8%; partial response, 20.7%). Myelosuppression was the dominant toxicity; 2 patients had toxic deaths related to thrombocytopenia with trauma. The 5\u2010year overall survival (OS) was 49% \u00b1 7%, and the progression\u2010free survival (PFS) was 31% \u00b1 7%, with a median follow\u2010up of 11.4 years (range, 5.2\u201015.0 years). For medulloblastoma, the 5\u2010year PFS was 26% \u00b1 9%; for EP it was 33% \u00b1 10%; for CPCA it was 80% \u00b1 18%; and for primitive neuroectodermal and atypical teratoid rhabdoid tumors it was 0%. Localized EP patients with gross total resection who did not undergo radiotherapy had a 5\u2010year PFS of 57% \u00b1 17% and OS of 71% \u00b1 16%. Two patients developed late second malignancies; 1 was associated with germline p53 mutation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The results confirm that carboplatin has similar activity to cisplatin in otherwise similar regimens. Five\u2010year survival data are comparable to those reported in other recent studies, including high\u2010dose chemotherapy studies. Of note is the marked activity in CPCA and gross totally resected EP. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.24362","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T16:45:00Z","timestamp":1243615500000},"page":"3243-3253","source":"Crossref","is-referenced-by-count":29,"title":["Carboplatin\u2010based primary chemotherapy for infants and young children with CNS 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