{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:44:46Z","timestamp":1789937086302,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The current study aimed to evaluate the efficacy of superselective high\u2010dose cisplatin infusion with concomitant radiotherapy (RADPLAT) for previously untreated patients with advanced cancer of the nasal cavity and paranasal sinuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Between October 1999 and December 2006, 47 patients were given superselective intra\u2010arterial infusions of cisplatin (100\u2010120 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      per week) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional external\u2010beam radiotherapy (65\u201070 grays).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>There were 7 patients (14.9%) diagnosed with T3, 22 (46.8%) with T4a, and 18 (38.3%) with T4b disease. During the median follow\u2010up period of 4.6 years, the 5\u2010year local progression\u2010free survival rate was 78.4% for all patients (n = 47), 69.0% for patients with T4b disease (n = 18), and 83.2% for patients with &lt;T4b disease (n = 29). The 5\u2010year overall survival rate was 69.3% for all patients, 61.1% for patients with T4b disease, and 71.1% for patients with &lt; T4b disease. RADPLAT was feasible in 45 patients (95.7%). No patient died as a result of treatment toxicity or had a cerebrovascular accident. Osteonecrosis (n = 7), brain necrosis (n = 2), and ocular\/visual problems (n = 16) were observed as late adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Although a single institution experience, the results of the current study suggest that RADPLAT can cure the majority of patients with advanced cancer of the nasal cavity and paranasal sinuses, as well as preserve organs. Late adverse reactions should be monitored in future studies. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.24515","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T15:54:49Z","timestamp":1248450889000},"page":"4705-4714","source":"Crossref","is-referenced-by-count":111,"title":["Superselective high\u2010dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal 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