{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:57Z","timestamp":1790812737468,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2009,7,27]],"date-time":"2009-07-27T00:00:00Z","timestamp":1248652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Cancer treatment is associated with decline in measured and self\u2010reported physical function and increased pain. In the current study, the authors evaluated the impact of a walking intervention on these outcomes during chemotherapy\/radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Patients with breast, prostate, and other cancers (N=126) were randomized to a home\u2010based walking intervention (exercise) or usual care (control). Exercise dose during the intervention was assessed using a 5\u2010item Physical Activity Questionnaire. Outcome measures were cardiorespiratory fitness, expressed as peak oxygen uptake (VO<jats:sub>2<\/jats:sub>) measured during treadmill testing (n = 85) or estimated by 12\u2010minute walk (n = 27), and self\u2010reported physical function, role limitations, and pain derived from Medical Outcomes Study Short Form 36. Linear regression was used to evaluate pre\u2010to\u2010post intervention change outcomes between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The mean (standard deviation) age of the patients was 60.2 (10.6) years. Diagnoses included prostate (55.6%) and breast (32.5%) cancer. Treatment included external beam radiotherapy (52.3%) and chemotherapy (34.9%). Exercise patients reported worsening Medical Outcomes Study physical function role limitations by the end of cancer treatment (<jats:italic>P<\/jats:italic> = .037). Younger age was associated with improved Medical Outcomes Study physical function (<jats:italic>P<\/jats:italic> = .048). In all patients, increased exercise dose was associated with decreased Medical Outcomes Study pain (<jats:italic>P<\/jats:italic> = .046), regardless of diagnosis. The percent change of VO<jats:sub>2<\/jats:sub> between prostate and nonprostate cancer patients when adjusted for baseline VO<jats:sub>2<\/jats:sub> and Physical Activity Questionnaire values was 17.45% (<jats:italic>P<\/jats:italic> = .008), with better VO<jats:sub>2<\/jats:sub> maintenance in the prostate group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Exercise during cancer treatment improves cardiorespiratory fitness and self\u2010reported physical function in prostate cancer patients and in younger patients, regardless of diagnosis, and may attenuate loss of those capacities in patients undergoing chemotherapy. Exercise also reduces the pain experience. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24551","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T02:45:42Z","timestamp":1248749142000},"page":"4874-4884","source":"Crossref","is-referenced-by-count":90,"title":["Impact of a walking intervention on cardiorespiratory fitness, self\u2010reported physical function, and pain in patients undergoing treatment for solid tumors"],"prefix":"10.1002","volume":"115","author":[{"given":"Kathleen","family":"Griffith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingJing","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,5]]},"reference":[{"issue":"3","key":"e_1_2_6_2_2","first-page":"4","article-title":"Patient, caregiver, and oncologist perceptions of cancer\u2010related fatigue: results of a tripart assessment survey. 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