{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:44:35Z","timestamp":1774007075611,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this study was to compare the clinical features and prognosis of patients with diffuse large B\u2010cell lymphoma (DLBCL) of Waldeyer ring (WR\u2010DLBCL) and patients with lymph node DLBCL (N\u2010DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>One hundred eighty\u2010one patients with WR\u2010DLBCL and N\u2010DLBCL were reviewed. There were 57 patients with stage I disease, 83 patients with stage II disease, 26 patients with stage III disease, and 15 patients with stage IV disease. Among them, 101 patients had primary N\u2010DLBCL, and 80 patients had primary WR\u2010DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Patients with WR\u2010DLBCL and N\u2010DLBCL usually presented at an older age and had localized disease, a low frequency of B symptoms, a good performance status, and a low\u2010risk International Prognostic Index (IPI) score. Compared with patients who had N\u2010DLBCL, patients who had WR\u2010DLBCL presented with more stage II disease and lower tumor burdens. The overall response rate after treatment was similar in both groups. The 5\u2010year overall survival (OS) and progression\u2010free survival (PFS) rates were 76% and 61% in patients with WR\u2010DLBCL, respectively, and 56% and 50% in patients with N\u2010DLBCL, respectively (<jats:italic>P<\/jats:italic> = .119 for OS; <jats:italic>P<\/jats:italic> = .052 for PFS). IPI scores and elevated \u03b22\u2010microglobulin and LDH levels were associated with a poor prognosis for patients who had WR\u2010DLBCL; whereas bulky tumor, elevated \u03b22\u2010microglobulin levels, and IPI scores were associated with poor OS for patients who had N\u2010DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results supported the continued inclusion of WR\u2010DLBCL as a lymph node group in the staging of DLBCL. Patients with WR\u2010DLBCL had clinical features and prognosis similar to those of patients with N\u2010DLBCL. Cancer 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24557","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T15:54:25Z","timestamp":1248450865000},"page":"4980-4989","source":"Crossref","is-referenced-by-count":23,"title":["Diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"115","author":[{"given":"Shu\u2010Nan","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Xiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Wen","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Qiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00895.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04749.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.155"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90081-N"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097720"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1077"},{"key":"e_1_2_6_11_2","first-page":"105","article-title":"Prognostic 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