{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:47:46Z","timestamp":1788306466208,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T00:00:00Z","timestamp":1256169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Inflammatory myofibroblastic tumors (IMTs) are myofibroblastic lesions with unpredictable biologic behavior that occur at a young age. For this report, the authors investigated clinicopathologic features in a series of pediatric IMTs. The objective of the study was to identify morphologic or immunohistochemical prognostic markers and the possible pathogenic role of human herpes virus 8 (HHV\u20108).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Twenty\u2010six patients were observed over a period of 18 years. Clinical\/histologic data were reviewed, and immunohistochemical\/molecular studies were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Patients ages 8\u2012216 months (median age, 60 months) presented with tumors of the lung\u2010bronchus (8 patients), abdomen (17 patients), and thoracic wall (1 patient). Twenty\u2010one patients underwent complete excision, and microscopic or macroscopic residual disease was present in 5 of those patients. Chemotherapy was received by 5 patients. After a median follow\u2010up of 6.6 years, 24 patients were in complete remission, and 2 patients had died of disease. Local recurrences were observed in 6 patients (including 4 recurrences that occurred after a complete excision). Cytologic atypia, low inflammatory infiltrate, and a rich myxoid pattern were detected in patients who had recurrent disease or a poor prognosis. Anaplastic lymphoma kinase (ALK) was positive in 7 patients (including 2 patients with recurrent disease). No correlation between clusterin expression and prognosis was demonstrated. HHV\u20108 was identified in 1 pulmonary IMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>IMTs are locally aggressive lesions. In this series, the local recurrence rate was 23%, and the 5\u2010year and 10\u2010year event\u2010free survival rates were 87.4% and 72.8%, respectively. The results indicated that the treatment of choice is a complete, nonmutilating excision; chemotherapy may be given to patients who have microscopic or macroscopic residual disease, although the results are controversial; cytologic atypia and positive ALK status are more frequent in aggressive tumors, whereas metastatic tumors are negative for ALK; and HHV8 is not involved in the pathogenesis of IMT. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24684","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T10:16:50Z","timestamp":1256206610000},"page":"216-226","source":"Crossref","is-referenced-by-count":86,"title":["Inflammatory myofibroblastic tumors in childhood"],"prefix":"10.1002","volume":"116","author":[{"given":"Rita","family":"Alaggio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cecchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Gambini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Inserra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Boldrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"De Salvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele S.","family":"G. d'Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Dall'Igna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199508000-00001"},{"key":"e_1_2_7_3_2","first-page":"85","article-title":"Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathologic survey","volume":"15","author":"Coffin CM","year":"1998","journal-title":"Semin Diagn Pathol."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199112000-00005"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.049387"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950200216"},{"key":"e_1_2_7_7_2","first-page":"1452","article-title":"Inflammatory pseudotumor of the liver in a patient with chronic sclerosing cholangitis","volume":"88","author":"Gough J","year":"1993","journal-title":"Am J Gastroenterol."},{"key":"e_1_2_7_8_2","first-page":"921","article-title":"Inflammatory pseudotumor of the spleen","volume":"117","author":"Thomas RM","year":"1993","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_7_9_2","first-page":"238","article-title":"Inflammatory pseudotumor of the liver associated with acute myelomonocytic leukemia","volume":"86","author":"Isobe H","year":"1991","journal-title":"Am J Gastroenterol."},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01121.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90674-I"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.18340"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.02.034"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02163.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780118"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200208000-00021"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880352"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213393.57322.c7"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.06.021"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000115)85:2<296::AID-IJC23>3.0.CO;2-Q"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0096-5588(20)32030-4","article-title":"Two interesting benign tumors of contradictory histopathology","volume":"9","author":"Brunn H","year":"1939","journal-title":"J Thorac Surg."},{"key":"e_1_2_7_22_2","first-page":"55","article-title":"Post\u2010inflammatory tumors of the lung","volume":"28","author":"Umiker WO","year":"1954","journal-title":"J Thorac Surg."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-004-1155-1"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01372155"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2004.00206.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199704)23:4<307::AID-PPUL8>3.0.CO;2-I"},{"key":"e_1_2_7_27_2","first-page":"1138","article-title":"Inflammatory pseudotumor of the ileum","volume":"118","author":"Mynt MA","year":"1994","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11466.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.23970"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930915)72:6<2042::AID-CNCR2820720641>3.0.CO;2-I"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20294"},{"key":"e_1_2_7_32_2","first-page":"153","article-title":"Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy","volume":"25","author":"Dishop MK","year":"2003","journal-title":"J Pediatr Surg."},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-8088-5"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90291-9"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.03.016"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000026615.04130.1F"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200111000-00003"},{"key":"e_1_2_7_38_2","first-page":"207","article-title":"Seroprevalence of Kaposi's sarcoma\u2010associated herpesvirus\/human herpesvirus 8 in several regions of Italy","volume":"1","author":"Calabr\u00f3 ML","year":"1998","journal-title":"J Hum Virol."},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00490.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.29679"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.24684","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.24684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:22:33Z","timestamp":1760278953000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.24684"}},"subtitle":["A report from the Italian Cooperative Group studies"],"short-title":[],"issued":{"date-parts":[[2009,10,22]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/cncr.24684"],"URL":"https:\/\/doi.org\/10.1002\/cncr.24684","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,22]]}}}