{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:54:47Z","timestamp":1790042087007,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Interleukin\u201015 (IL\u201015) has been associated with the growth, survival and biological behavior of leukemic cells and response to therapy. We determined the expression of IL\u201015 in lymphoblasts and evaluated its potential impact on the outcome in adult acute lymphoblastic leukemia (ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Between June 1999 and June 2006, ALL samples were collected from 87 adult patients before initiation of antineoplastic therapy. These patients were enrolled in the German Multicenter Acute Lymphoblastic Leukemia June 1999 and July 2003 study trials. The expression of IL\u201015 in leukemic cells was analyzed by real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The expression of IL\u201015 correlated with the immunophenotype: T\u2010lineage ALL had a more than 4\u2010fold higher IL\u201015 mRNA expression as compared with B\u2010cell precursor (BCP)\u2010ALL (<jats:italic>P<\/jats:italic> &lt; .001). Patients with <jats:italic>BCR\u2010ABL<\/jats:italic><jats:sup>+<\/jats:sup>\u2010BCP\u2010ALL had lower IL\u201015 expression compared with <jats:italic>BCR\u2010ABL<\/jats:italic><jats:sup>\u2212<\/jats:sup>\u2010BCP\u2010ALL (<jats:italic>P<\/jats:italic> = .041). Furthermore, higher expression of IL\u201015 was associated with mediastinal (<jats:italic>P<\/jats:italic> = .001) and lymph node infiltration (<jats:italic>P<\/jats:italic> = .051), but not with hepatomegaly and splenomegaly. Notably, high IL\u201015 expression in BCP\u2010ALL was associated with an inferior relapse\u2010free survival (RFS) at 5 years (0.17 \u00b1 0.13 vs 0.47 \u00b1 0.13) (<jats:italic>P<\/jats:italic> = .008), but there was no impact on overall survival (<jats:italic>P<\/jats:italic> = .249).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Differential expression of IL\u201015 in adult ALL at diagnosis was associated with clinical features and outcome, in particular, RFS. It remains to be evaluated whether IL\u201015 might be a relevant therapy target, or might be used for risk stratification. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24729","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T18:49:18Z","timestamp":1258570158000},"page":"387-392","source":"Crossref","is-referenced-by-count":23,"title":["Expression of interleukin 15 in primary adult acute lymphoblastic 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