{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:26:22Z","timestamp":1784899582784,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T00:00:00Z","timestamp":1259712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Colorectal cancer is exceedingly rare in children and adolescents. Reports from small series indicate that poor prognostic factors are more common in children than in adults, resulting in worse outcome for the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results database was searched for records of children\/adolescents with colorectal cancer, and the features and outcomes were compared with those of adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>From January 1973 through December 2005, only 159 children\/adolescents (ages 4\u201020 years) were reported with a diagnosis of colorectal cancer. The most common sites of involvement were the rectum (27%) and the transverse colon (26%). Adenocarcinoma was the most common histiotype in both adults and pediatric patients; however, children\/adolescents had more unfavorable histiotypes (ie, mucinous adenocarcinoma [22%] and signet ring cell carcinoma [18%]) when compared with adults (10% and 1%, respectively; <jats:italic>P<\/jats:italic> &lt; .001). Poorly differentiated and undifferentiated tumors (grades III and IV, respectively) and distant stage were more common in children\/adolescents (<jats:italic>P<\/jats:italic> &lt; .001). The 5\u2010year relative survival estimates in children\/adolescents and adults were 40% \u00b1 4.2% and 60% \u00b1 0.10%, respectively, confirming a worse outcome in the pediatric age group (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Children\/adolescents represent a minority of patients with colorectal cancer and have high\u2010risk features and worse outcome than adults. The small number of patients in this age group was an impediment to the development of meaningful clinical trials. Thus, the principles of management for adult colorectal cancer should be used in the treatment of children and adolescents. Cancer 2010. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24777","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T15:07:25Z","timestamp":1259766445000},"page":"758-765","source":"Crossref","is-referenced-by-count":138,"title":["Distinct features of colorectal cancer in children and adolescents"],"prefix":"10.1002","volume":"116","author":[{"given":"Iyad","family":"Sultan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rodriguez\u2010Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"El\u2010Taani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Gallino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00486-7"},{"key":"e_1_2_6_3_2","first-page":"1172","volume-title":"Principles and Practice of Pediatric Oncology","author":"Pappo AS","year":"2006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.028"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22049"},{"key":"e_1_2_6_6_2","volume-title":"Surveillance, Epidemiology, and End Results (SEER) Program SEER*Stat Database: Incidence\u2010SEER 17 Regs Limited\u2010Use + Hurricane Katrina Impacted Louisiana Cases, Nov 2007 Submission (1973\u20102005 varying)\u2010Linked To County Attributes\u2010Total U.S., 1969\u20102005 Counties","year":"2008"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"e_1_2_6_9_2","unstructured":"DeanAG SullivanKM SoeMM. 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