{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:13:45Z","timestamp":1761765225593,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T00:00:00Z","timestamp":1259712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Some men with a postradiation therapy (RT) prostate\u2010specific antigen (PSA) recurrence will die of noncancer causes before developing metastases. Therefore, our ability to determine who would benefit from salvage hormonotherapy (HT) would be enhanced if an individual's risk of nonprostate\u2010cancer\u2010specific mortality were known.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Among 206 men with unfavorable\u2010risk localized prostate cancer initially randomized to RT+\/\u2212HT, 87 men who experienced PSA recurrence were studied. Fine and Gray's competing risks regression was used to assess whether body mass index (BMI) and the Adult Comorbidity Evaluation\u201027 comorbidity level at randomization were associated with the risk of nonprostate\u2010cancer\u2010specific mortality after PSA recurrence, adjusting for age at recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>After a median postrecurrence follow\u2010up of 4.4 years, moderate\/severe comorbidity (adjusted hazard ratio [HR] = 3.15; <jats:italic>P<\/jats:italic> = .02), BMI \u2265 median (27.4 kg\/m<jats:sup>2<\/jats:sup>; adjusted HR=2.98; p=.04), and increasing age at recurrence (adjusted HR = 1.17; <jats:italic>P<\/jats:italic> = .03) were significantly associated with an increased risk of nonprostate\u2010cancer\u2010specific mortality. Five\u2010year cumulative incidence estimates of nonprostate\u2010cancer\u2010specific mortality were as follows: 0% (95% confidence interval [CI] [0,0]) for low\u2010risk patients (mild\/no comorbidity and age&lt;median [76.2 years] and BMI&lt;median), 18.8% (5.8\u201031.8) for intermediate\u2010risk patients (mild\/no comorbidity and either age\u2265median or BMI\u2265median); and 37.9% (95% CI, 6.8\u201068.9) for high\u2010risk patients (moderate\/severe comorbidity; <jats:italic>P<\/jats:italic> = .03 overall).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>After a post\u2010RT PSA recurrence, men with moderate\/severe comorbidity and those who are obese or older face a substantial risk of nonprostate\u2010cancer\u2010specific mortality, and they could be considered for surveillance protocols with a plan to initiate salvage HT if the PSA rises rapidly (eg, PSA doubling time &lt;6 months) or the patient develops clinically or radiographically evident disease. Cancer 2010. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24818","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T15:07:12Z","timestamp":1259766432000},"page":"610-615","source":"Crossref","is-referenced-by-count":11,"title":["Comorbidity, body mass index, and age and the risk of nonprostate\u2010cancer\u2010specific mortality after a postradiation prostate\u2010specific antigen recurrence"],"prefix":"10.1002","volume":"116","author":[{"given":"Paul L.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clair J.","family":"Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Warren","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni K.","family":"Choueiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Efstathiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Loffredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.","family":"Kantoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony V.","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000111844.95024.74"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1598"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.1949"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1591"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00123-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.029"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.20.2441"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1210"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1993.10476289"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"volume-title":"Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults","year":"1998","author":"US Department of Health and Human Services","key":"e_1_2_6_13_2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22279"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.0007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg043"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.11.1325"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000127734.01845.99"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62406-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.07.019"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00208-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06066.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2497"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.24818","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.24818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:58:34Z","timestamp":1760302714000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.24818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,2]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/cncr.24818"],"URL":"https:\/\/doi.org\/10.1002\/cncr.24818","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"type":"print","value":"0008-543X"},{"type":"electronic","value":"1097-0142"}],"subject":[],"published":{"date-parts":[[2009,12,2]]}}}