{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:25:58Z","timestamp":1769023558387,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,2,16]],"date-time":"2010-02-16T00:00:00Z","timestamp":1266278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Combined long\u2010term androgen deprivation (LTAD) and radiation conveys a prostate cancer\u2010specific survival advantage over combined short\u2010term androgen deprivation (STAD) and radiation. The seminal question is whether or not the gains are worth the adverse effects of LTAD with respect to patient preferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Preferences for LTAD compared with STAD were elicited by direct patient interview using the probability trade\u2010off method. \u201cTime trade\u2010off utilities\u201d (TTOu) for erectile dysfunction and osteoporosis were elicited using the time trade\u2010off method. Participants' current prostate cancer\u2010specific health state was assessed using the Patient\u2010Oriented Prostate Utility Scale\u2010Psychometric. Participants' current sexual function was assessed using the International Index of Erectile Function (IIEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>All participants were willing to trade survival rather than undergo LTAD compared with STAD. The mean minimally required increment in prostate cancer\u2010specific survival (MRIS) was 8.2%. The mean TTOu for impotence was 0.78, and the mean TTOu for osteoporosis was 0.71. The MRIS was correlated with the Sexual Desire domain score of the IIEF (Spearman rank\u2010correlation coefficient, <jats:italic>r<\/jats:italic> = 0.50; <jats:italic>P<\/jats:italic>&lt;.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Patients desired more prostate cancer\u2010specific survival than what was afforded by LTAD and radiotherapy compared with STAD and radiotherapy. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.24905","type":"journal-article","created":{"date-parts":[[2010,2,16]],"date-time":"2010-02-16T13:50:48Z","timestamp":1266328248000},"page":"1909-1917","source":"Crossref","is-referenced-by-count":22,"title":["Sex or survival"],"prefix":"10.1002","volume":"116","author":[{"given":"Derek R.","family":"Wilke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Krahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bezjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rutledge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padraig","family":"Warde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.12.1017"},{"key":"e_1_2_6_3_2","first-page":"1314","article-title":"Radiation Oncologist Group. 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