{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:07:07Z","timestamp":1779232027861,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:00:00Z","timestamp":1270771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Genetic variants of DNA repair enzymes may lead to genetic instability and contribute to gallbladder (GB) carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A case\u2010control study (230 GB carcinogenesis patients and 230 controls) was undertaken to evaluate whether genetic variations in 3 DNA repair genes <jats:italic>ERCC2<\/jats:italic> (Asp312Asn [rs1799793] and Lys751Gln [rs13181]), <jats:italic>MSH2<\/jats:italic> (\u2212118T&gt;C [rs2303425] and IVS1 + 9G&gt;C [rs2303426]), and <jats:italic>OGG1<\/jats:italic> (Ser326Cys [rs1052133] and 748\u201015C&gt;G [rs2072668]) are associated with GB carcinogenesis risk in a North Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The authors found that the <jats:italic>ERCC2<\/jats:italic> Asp312Asn AA, <jats:italic>MSH2<\/jats:italic> IVS1 + 9G&gt;C CC, <jats:italic>OGG1<\/jats:italic> Ser326Cys GG and CG + GG, and <jats:italic>OGG1<\/jats:italic> 748\u201015C&gt;G GG and CG + GG genotypes were significantly associated with an increased risk of GB carcinogenesis (odds ratio [OR], 2.1, 1.8, 2.5, 1.8, 2.0, and 1.6, respectively). In contrast, <jats:italic>ERCC2<\/jats:italic> Lys751Gln, and <jats:italic>MSH2<\/jats:italic> \u2212118T&gt;C markers showed no significant associations with GB carcinogenesis risk, although because of the small sample size their effects cannot be ruled out. Female GB carcinogenesis patients with the <jats:italic>OGG1<\/jats:italic> 748\u201015C&gt;G GG, <jats:italic>OGG1<\/jats:italic> Ser326Cys GG, and <jats:italic>ERCC2<\/jats:italic> Asp312Asn genotypes had a greater risk for developing the disease (OR, 3.6, 7.7, and 2.7, respectively). There was a significant interaction between <jats:italic>MSH2<\/jats:italic> IVS1 + 9G&gt;C and <jats:italic>OGG1<\/jats:italic> 748\u201015C&gt;G polymorphisms (<jats:italic>P<\/jats:italic> = .001). Furthermore, individuals with &gt;6 variant alleles of the studied polymorphisms were at 4\u2010fold increased risk for developing GB carcinogenesis. Classification and Regression Tree analysis revealed potential higher\u2010order gene\u2010gene interactions and categorized a few higher\u2010risk subgroups for GB carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>These results suggest that genetic variants in the DNA repair pathways may be involved in GB carcinogenesis etiology. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25063","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T13:48:53Z","timestamp":1271080133000},"page":"3160-3169","source":"Crossref","is-referenced-by-count":51,"title":["Polymorphisms in <i>ERCC2<\/i>, <i>MSH2<\/i>, and <i>OGG1<\/i> DNA repair genes and gallbladder cancer risk in a population of Northern 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