{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:31:18Z","timestamp":1769635878802,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T00:00:00Z","timestamp":1269820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>European Urological Association guidelines recommend potentially curative inguinal lymphadenectomy for certain cases of penile cancer such as grade 3 and pT2\u20104 lesions, among others. Anecdotally, the authors have noticed that few patients undergo inguinal lymphadenectomy. Therefore, they assessed the frequency of inguinal lymphadenectomy and the impact of dissection extent on survival using the Surveillance, Epidemiology, and End Results (SEER) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors queried 17 SEER registries from 1988 through 2005 for grade 3 and pT2\u20104 penile cancer patients without distant metastases. Univariate and multivariate analyses examined predictors of inguinal lymphadenectomy. Kaplan\u2010Meier and Cox regression analyses assessed overall 5\u2010year survival across patient\u2010 and disease\u2010related characteristics for patients receiving inguinal lymphadenectomy involving &lt;8 or \u22658 lymph nodes, the latter a surrogate for extent of dissection based on other malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 593 patients enrolled, only 26.5% received inguinal lymphadenectomy. In addition to grade 3 (<jats:italic>P<\/jats:italic> = .031) and pT2\u20104 disease (<jats:italic>P<\/jats:italic> = .004), age &lt;65 years (<jats:italic>P<\/jats:italic> &lt; .001) and marital status (<jats:italic>P<\/jats:italic> = .002) were significantly associated with receiving lymph node dissection. Increased overall 5\u2010year survival (hazard ratio, 0.54; 95% confidence interval, 0.36\u20100.79) was observed in patients of all ages who received lymphadenectomy involving \u22658 lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>A significant number of penile cancer patients at risk for metastases have not received potentially curative inguinal lymphadenectomy. Patients receiving inguinal lymphadenectomy involving \u22658 lymph nodes experienced improved overall 5\u2010year survival. Guidelines should not only be given more emphasis, but possibly be updated to reflect the benefit of extensive lymph node dissection in high\u2010risk penile cancer patients. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25091","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T11:35:43Z","timestamp":1269862543000},"page":"2960-2966","source":"Crossref","is-referenced-by-count":82,"title":["Extensive inguinal lymphadenectomy improves overall 5\u2010year survival in penile cancer patients"],"prefix":"10.1002","volume":"116","author":[{"given":"Timothy V.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayland","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Delman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashesh B.","family":"Jani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otis W.","family":"Brawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraj A.","family":"Master","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.06.024"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.03.007"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00380.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07773.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20414"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00379.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66450-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0324-6"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38068-0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66671-0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66337-9"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07744.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023243102230"},{"key":"e_1_2_7_15_2","unstructured":"National Comprehensive Cancer Network I. Melanoma. NCCN Clinical Practice Guidelines in Oncology. Available at: V. 2.2009:http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/melanoma.pdfAccessed February 24 2009."},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318194d38f"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21253"},{"key":"e_1_2_7_18_2","unstructured":"National Cancer Institute. Surveillance Epidemiology and End Results (SEER) Program SEER*Stat Database. Available at:www.seer.cancer.govAccessed July 2009."},{"key":"e_1_2_7_19_2","article-title":"Leg endoscopic groin lymphadenectomy (LEG procedure): step\u2010by\u2010step approach to a straightforward technique","author":"Master V","year":"2010","journal-title":"Eur Urol."},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.07.014"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.25091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.25091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:36:54Z","timestamp":1760287014000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.25091"}},"subtitle":["Results from the Surveillance, Epidemiology, and End Results program"],"short-title":[],"issued":{"date-parts":[[2010,6,11]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,6,15]]}},"alternative-id":["10.1002\/cncr.25091"],"URL":"https:\/\/doi.org\/10.1002\/cncr.25091","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,11]]}}}