{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:22:57Z","timestamp":1791868977303,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Given the indolent behavior of follicular lymphoma (FL), it is controversial whether limited stage FL can be cured using radiotherapy (RT). Furthermore, the optimal RT field size is unclear. The authors of this report investigated the long\u2010term outcomes of patients with limited stage FL who received RT alone and studied the impact of reducing the RT field size from involved regional RT (IRRT) to involved node RT with margins up to 5 cm (INRT\u22645 cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Eligible patients had limited stage, grade 1 through 3A FL diagnosed between 1986 and 2006 and treated were with curative\u2010intent RT alone. IRRT encompassed the involved lymph node group plus \u22651 adjacent, uninvolved lymph node group(s). INRT\u22645 cm covered the involved lymph node(s) with margins \u22645 cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>In total, 237 patients were identified (median follow\u2010up, 7.3 years) and included 48% men, 54% aged &gt;60 years, stage IA disease in 76% of patients, elevated lactate dehydrogenase (LDH) in 7% of patients, grade 3A tumors in 12% of patients, and lymph node size \u22655 cm in 19% of patients. The 2 RT groups were IRRT (142 patients; 60%) and INRT\u22645 cm (95 patients; 40%). At 10 years, the progression\u2010free survival (PFS) rate was 49%, and the overall survival (OS) rate was 66%. Only 2 patients developed recurrent disease beyond 10 years. The most common pattern of first failure was a distant recurrence only, which developed in 38% of patients who received IRRT and in 32% of patients who received INRT\u22645 cm. After INRT\u22645 cm, 1% of patients had a regional\u2010only recurrence. Significant risk factors for PFS were lymph nodes \u22655 cm (<jats:italic>P<\/jats:italic> = .008) and male gender (<jats:italic>P<\/jats:italic> = .042). Risk factors for OS were age &gt;60 years (<jats:italic>P<\/jats:italic> &lt; .001), elevated LDH (<jats:italic>P<\/jats:italic> = .007), lymph nodes \u22655 cm (<jats:italic>P<\/jats:italic> = .016), and grade 3A tumors (<jats:italic>P<\/jats:italic> = .036). RT field size did not have an impact on PFS or OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Disease recurrence after 10 years was uncommon in patients who had limited stage FL, suggesting that a cure is possible. Reducing RT fields to INRT\u22645 cm did not compromise long\u2010term outcomes. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25117","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T21:10:48Z","timestamp":1274908248000},"page":"3797-3806","source":"Crossref","is-referenced-by-count":107,"title":["Long\u2010term outcomes for patients with limited stage follicular lymphoma"],"prefix":"10.1002","volume":"116","author":[{"given":"Belinda A.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Pickles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"The Non\u2010Hodgkin's Lymphoma Classification Project","volume":"89","year":"1997","journal-title":"Blood."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/2.suppl_2.137"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90028-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.4.1282"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01747-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(95)01600-L"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.08.010"},{"issue":"14","key":"e_1_2_6_9_2","article-title":"Long\u2010term outcome in stage I and II follicular lymphoma following treatment with involved field radiation therapy alone [abstract]","volume":"22","author":"Petersen PM","year":"2004","journal-title":"J Clin Oncol."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp148"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2006.0025"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2008.0030"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1495"},{"key":"e_1_2_6_14_2","volume-title":"Adult Non\u2010Hodgkin Lymphoma Treatment. Physicians' Data Query (PDQ) comprehensive cancer database","author":"National Cancer Institute","year":"2009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_6_16_2","volume-title":"SPSS for Windows 14.0","author":"SPSS Inc.","year":"2005"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2004.1.203"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802311409"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.216"},{"key":"e_1_2_6_21_2","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Non\u2010Hodgkin's Lymphomas","author":"National Comprehensive Cancer Network, Inc.","year":"2009"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.05.015"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.1001"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.25117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.25117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:44:07Z","timestamp":1760262247000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.25117"}},"subtitle":["Involved regional radiotherapy versus involved node radiotherapy"],"short-title":[],"issued":{"date-parts":[[2010,8,4]]},"references-count":22,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,8,15]]}},"alternative-id":["10.1002\/cncr.25117"],"URL":"https:\/\/doi.org\/10.1002\/cncr.25117","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,4]]}}}