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The objective of the current study was to analyze a series of 42 patients with both MM and RCC to identify clinical and pathologic features as well as risk factors of this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Clinical and pathologic characteristics of 42 patients who developed both MM and RCC (the MM + RCC series) were compared with 2 published series in each cancer alone: a series of 293 patients with MM (MM series) and a series of 1527 patients with RCC (RCC series).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>RCC was diagnosed concomitantly or after MM in 83% of patients in the MM + RCC series. Those patients displayed a high proportion of asymptomatic RCC at diagnosis (70%) and a higher frequency of stage I tumors (61%) than patients in the RCC series. Compared with the MM series, patients in the MM + RCC series more often were men, had a higher frequency of blond\/red hair, had poor tanning ability, and had a higher number of nevi. In addition, patients in the MM + RCC series had a high aggregation of other malignancies (mainly skin cancers) and a significantly higher frequency of family history of MM (<jats:italic>P<\/jats:italic> = .005). Only 2 cyclin\u2010dependent kinase 2A gene (<jats:italic>CDKN2A<\/jats:italic>) germline mutations were identified among patients in the MM + RCC series who also were members of MM\u2010prone families.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The high aggregation of cancers among patients in the MM + RCC series and the familial clustering of MM argued for a genetic predisposition that may be partly independent of <jats:italic>CDKN2A<\/jats:italic>. Cancer 2010. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25562","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T19:17:26Z","timestamp":1283282246000},"page":"5716-5724","source":"Crossref","is-referenced-by-count":21,"title":["Characteristics of the coexistence of melanoma and renal cell carcinoma"],"prefix":"10.1002","volume":"116","author":[{"given":"Eve","family":"Maubec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Chaudru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Mohamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Patard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Crickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte Bressac\u2010de","family":"Paillerets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Demenais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Fran\u00e7oise","family":"Avril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79560-0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.03.010"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.12.894"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0715-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.161"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.411"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2008.03.117"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm170"},{"key":"e_1_2_7_10_2","first-page":"1001","article-title":"Family history and risk of renal cell carcinoma","volume":"10","author":"Gago\u2010Dominguez M","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0601"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1364"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<2014::AID-CNCR19>3.0.CO;2-4"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.45"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.2"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62510-2"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06004.x"},{"key":"e_1_2_7_18_2","first-page":"285","volume-title":"New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973\u20102000. 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