{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:55:32Z","timestamp":1788404132284,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Hyperinsulinemia and the metabolic syndrome are both risk factors for breast cancer. It is not clear if diabetes is associated with the risk of breast cancer in women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors reviewed the medical histories of 6052 women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation, half of whom had been diagnosed with breast cancer. They estimated the odds ratio for breast cancer, given a self\u2010report of diabetes. They then estimated the hazard ratio for a new diagnosis of diabetes associated with a history of breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>There was no excess of diabetes in the period before the diagnosis of breast cancer, compared with controls with no diagnosis of breast cancer. The risk of diabetes was doubled among <jats:italic>BRCA<\/jats:italic> carriers in the 15\u2010year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4\u20102.8; <jats:italic>P<\/jats:italic> = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index (BMI) &gt;25.0 kg\/m<jats:sup>2<\/jats:sup> (odds ratio, 5.8; 95% CI, 4.0\u20108.6; <jats:italic>P<\/jats:italic> = .0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>After a diagnosis of breast cancer, women with a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation face a 2\u2010fold increase in the risk of diabetes, which is exacerbated by a high BMI. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25595","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T12:20:06Z","timestamp":1289391606000},"page":"1812-1818","source":"Crossref","is-referenced-by-count":68,"title":["Diabetes and breast cancer among women with <i>BRCA1<\/i> and <i>BRCA2<\/i> mutations"],"prefix":"10.1002","volume":"117","author":[{"given":"Louise","family":"Bordeleau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Lipscombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Ghadirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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