{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:50:07Z","timestamp":1789995007937,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T00:00:00Z","timestamp":1288656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND.<\/jats:title><jats:p><jats:italic>BRCA1<\/jats:italic>\u2010associated breast cancer had been shown to be morphologically and genetically distinct from sporadic cancers. The aim of this study was to determine the association of CK8\/18 with <jats:italic>BRCA1<\/jats:italic>\u2010associated tumors and if, by using CK8\/18 and basal biomarkers in conjunction with morphologic features and family history characteristics, the specificity of the <jats:italic>BRCA1<\/jats:italic>\u2010associated tumor profile in a pathologically well\u2010characterized cohort would be improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS.<\/jats:title><jats:p>Fifty\u2010eight patients with known <jats:italic>BRCA1<\/jats:italic> germline mutations and 221 control (familial non\u2010<jats:italic>BRCA<\/jats:italic>) patients were selected from the Ontario Familial Breast Cancer Registry. From this database, information on family history and morphologic features was abstracted. Tissue microarrays were constructed and immunohistochemistry to determine expression of several biomarkers was performed. After a logistic regression fit, a best\u2010subsets variable\u2010selection procedure using model performance and predictive ability measures was applied to find a best predictor to distinguish <jats:italic>BRCA1<\/jats:italic>\u2010associated tumors from non\u2010<jats:italic>BRCA<\/jats:italic> associated tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS.<\/jats:title><jats:p><jats:italic>BRCA1<\/jats:italic>\u2010associated tumors differed significantly from control tumors in terms of morphology, family history, and biomarker profile. CK8\/18 was highly significantly associated with <jats:italic>BRCA1<\/jats:italic> tumors. Consistently, <jats:italic>BRCA1<\/jats:italic> cancers showed low levels of CK8\/18 compared to non\u2010<jats:italic>BRCA<\/jats:italic> tumors, whether they were basal\u2010like or not. A combination of 7 factors, including CK8\/18 and family history, best predicted the <jats:italic>BRCA1<\/jats:italic>\u2010associated cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS.<\/jats:title><jats:p>CK8\/18 expression was independently associated with <jats:italic>BRCA1<\/jats:italic>\u2010associated breast cancers. Reduced CK8\/18 expression in conjunction with the basal\u2010like phenotype and family history may have improved the ability to identify which tumors were likely to be associated with a <jats:italic>BRCA1<\/jats:italic> germline mutation and thereby help streamline genetic testing. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25642","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:36:01Z","timestamp":1288744561000},"page":"1350-1359","source":"Crossref","is-referenced-by-count":14,"title":["CK8\/18 expression, the basal phenotype, and family history in identifying <i>BRCA1<\/i>\u2010associated breast cancer in the Ontario site of the Breast Cancer Family Registry"],"prefix":"10.1002","volume":"117","author":[{"given":"Anna Marie","family":"Mulligan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushanthi","family":"Pinnaduwage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita L.","family":"Bane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley 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