{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:53:56Z","timestamp":1792043636437,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The aim of this study was to examine the effect of antineoplastic therapy on dental development and saliva function in recipients of childhood antineoplastic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Patients attending the long\u2010term follow\u2010up clinic at Children's Hospital at Westmead, NSW, Australia, were included if they had received treatment prior to 16 years of age and were in remission for more than 5 years. A dental examination and saliva test were performed for each participant. Holtta's Defect Index (HDI) was used to assess tooth aplasia, microdontia, and root\u2010crown ratio on an orthopantomogram (OPG). Multivariable\u2010adjusted regression analyses were used to estimate the association of patient characteristics and treatment modalities with dental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>One hundred six participants (61% male) were recruited (response rate = 88%). The mean HDI score was 24.7 \u00b1 17.8. A cumulative dose of cyclophosphamide &gt;7500 mg\/m<jats:sup>2<\/jats:sup> increased the HDI score by 13.06 (<jats:italic>P<\/jats:italic> = .01). Recipients of cyclophosphamide also had significantly increased odds of exhibiting very low saliva flow (&lt;0.7 mL\/min) (odds ratio = 12.43; 95% confidence interval, 2.08\u201074.35; <jats:italic>P<\/jats:italic> = .006).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances. Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow. This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose\u2010dependent relation between cumulative dose of cyclophosphamide and dental disturbances. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25704","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T12:38:22Z","timestamp":1291034302000},"page":"2219-2227","source":"Crossref","is-referenced-by-count":44,"title":["Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy"],"prefix":"10.1002","volume":"117","author":[{"given":"Susan Gyea\u2010Su","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hibbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Ahern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-0272(03)00025-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20762"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705111"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00089-1"},{"key":"e_1_2_6_6_2","unstructured":"HolttaP.Developmental aberrations of permanent teeth after high\u2010dose anti\u2010cancer therapy in childhood. 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