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The frequency of these risk factors has increased in recent decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The purpose of this population\u2010based case\u2010control study was to examine associations between parity, age at first birth (AFB), and specific histological subtypes of breast cancer. Women with breast cancer were identified from cancer registries in Wisconsin, Massachusetts, and New Hampshire. Control subjects were randomly selected from population lists. Interviews collected information on reproductive histories and other risk factors. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of ductal, lobular, and mixed ductal\u2010lobular breast cancer diagnosis in association with AFB and nulliparity.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>AFB \u226530 years was associated with a 2.4\u2010fold increase in risk of lobular breast cancer compared with AFB &lt;20 years (OR, 2.4; 95% CI, 1.9\u20102.9). The association was less pronounced for ductal breast cancer (OR, 1.3; 95% CI, 1.2\u20101.4). Nulliparity was associated with increased risk for all breast cancer subtypes, compared with women with AFB &lt;20 years, but the association was stronger for lobular (OR, 1.7; 95% CI, 1.3\u20102.2) than for ductal (OR, 1.2; 95% CI, 1.1\u20101.3) subtypes <jats:italic>(P<\/jats:italic> = .004). The adverse effects of later AFB was stronger with obesity (<jats:italic>P<\/jats:italic> = .03) in lobular, but not ductal, breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Stronger associations observed for late AFB and nulliparity suggest that these factors preferentially stimulate growth of lobular breast carcinomas. Recent temporal changes in reproductive patterns and rates of obesity may impact the histological presentation of breast cancer. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25728","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T12:23:44Z","timestamp":1289391824000},"page":"1946-1956","source":"Crossref","is-referenced-by-count":31,"title":["Late age at first full term birth is strongly associated with lobular breast cancer"],"prefix":"10.1002","volume":"117","author":[{"given":"Polly A.","family":"Newcomb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Trentham\u2010Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Hampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Titus\u2010Ernstoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaneda","family":"Warren Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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