{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:46:38Z","timestamp":1764510398336,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T00:00:00Z","timestamp":1293580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Chromosomal translocation t(14;18)(q32;q21) involving the immunoglobulin heavy chain gene (<jats:italic>IGH<\/jats:italic>) and the <jats:italic>BCL2<\/jats:italic> gene (t[14;18][q32;q21]\/<jats:italic>IGH\u2010BCL2<\/jats:italic>) is present in 60% to 90% of nodal follicular lymphomas. To the authors' knowledge, the prevalence and clinical significance of this translocation have not been examined previously in gastrointestinal follicular lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Clinicopathologic and molecular features were investigated in 48 patients who had gastrointestinal follicular lymphoma. The site of involvement was the duodenum in 54% of patients, the jejunum in 52%, the ileum in 52%, the stomach in 29%, and the colorectum in 15%. The presence of the t(14;18)\/<jats:italic>IGH\u2010BCL2<\/jats:italic> translocation was detected by interphase fluorescence in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Treatment modalities included surgical resection (n = 16), rituximab plus chemotherapy (n = 13), rituximab alone (n = 6), antibiotics (n = 5), and watchful waiting (n = 8). Complete remission (CR) of lymphoma was achieved in 31 patients (65%). The overall survival and event\u2010free survival rates after 5 years were 93% and 68%, respectively. The t(14;18)\/<jats:italic>IGH\u2010BCL2<\/jats:italic> was detected in 39 patients (81%). The involvement of multiple sites (69% vs 0%), manifestation of the lymphomatous polyposis type (72% vs 22%), and histologic grade 1 or 2 tumors (92% vs 56%) were more frequent in the t(14;18)\u2010positive group than in the negative group. In addition, the CR rate was lower in the t(14;18)\u2010positive group than in the negative group (56% vs 100%; <jats:italic>P<\/jats:italic> = .0179), and a trend was observed toward poorer event\u2010free survival in the positive group (<jats:italic>P<\/jats:italic> = .089).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The t(14;18)\/<jats:italic>IGH\u2010BCL2<\/jats:italic> chromosomal translocation occurred frequently in gastrointestinal follicular lymphomas. The current results indicated that this translocation may be a predictor of an adverse clinical course. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25811","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T11:13:46Z","timestamp":1293621226000},"page":"2467-2477","source":"Crossref","is-referenced-by-count":12,"title":["Translocation t(14;18)\/<i>IGH\u2010BCL2<\/i> in gastrointestinal follicular lymphoma"],"prefix":"10.1002","volume":"117","author":[{"given":"Shunichi","family":"Yanai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Hirahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kurahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,29]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"220","volume-title":"WHO 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