{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:10:47Z","timestamp":1787735447331,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T00:00:00Z","timestamp":1292284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A total of 108 consecutive patients were treated with salvage radiation therapy to 65 grays (Gy) in 26 fractions of 2.5 Gy. Median follow\u2010up was 32.4 months. Median presalvage prostate\u2010specific antigen (PSA) was 0.44 (range, 0.05\u20109.50). Eighteen (17%) patients received androgen deprivation after surgery or concurrently with radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The actuarial freedom from biochemical failure for the entire group at 4 years was 67% \u00b1 5.3%. An identical 67% control rate was seen at 5 years for the first 50 enrolled patients, whose median follow\u2010up was longer at 43 months. One acute grade 3 genitourinary toxicity occurred, with no acute grade 3 gastrointestinal and no late grade 3 toxicities observed. On univariate analysis, higher Gleason score (<jats:italic>P<\/jats:italic> = .006), PSA doubling time \u226412 months (<jats:italic>P<\/jats:italic> = .03), perineural invasion (<jats:italic>P<\/jats:italic> = .06), and negative margins (<jats:italic>P<\/jats:italic> = .06) showed association with unsuccessful salvage. On multivariate analysis, higher Gleason score (<jats:italic>P<\/jats:italic> = .057) and negative margins (<jats:italic>P<\/jats:italic> = .088) retained an association with biochemical failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Hypofractionated radiotherapy (65 Gy in 2.5 Gy fractions in about 5 weeks) reduces the length of treatment by from 1\u2010\u00bd to 3 weeks relative to other treatment schedules commonly used, produces low rates of toxicity, and demonstrates encouraging efficacy at 4 to 5 years. Hypofractionation may provide a convenient, resource\u2010efficient, and well\u2010tolerated salvage approach for the estimated 20,000 to 35,000 US men per year experiencing biochemical recurrence after prostatectomy. Cancer 2011. \u00a9 2010 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25824","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T10:49:46Z","timestamp":1292323786000},"page":"2629-2636","source":"Crossref","is-referenced-by-count":66,"title":["Early hypofractionated salvage radiotherapy for postprostatectomy biochemical recurrence"],"prefix":"10.1002","volume":"117","author":[{"given":"Tim J.","family":"Kruser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Jarrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Hedican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Paolone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Wegenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Geye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,14]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"168","article-title":"Prostate cancer modality time trend analyses from 1973 to 2004: a Surveillance","volume":"33","author":"Jani AB","year":"2010","journal-title":"Epidemiology, and End Results registry analysis. Am J Clin Oncol."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000107247.81471.06"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.06.116"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67101-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.19.2329"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.9563"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.049"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.9607"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.11.1325"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.05.057"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.23.2760"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.042"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.067"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181976614"},{"key":"e_1_2_6_17_2","article-title":"Acute and late toxicity in a randomized trial of conventional versus hypofractionated three\u2010dimensional conformal radiotherapy for prostate cancer","author":"Arcangeli G","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1691"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/153303460300200511"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/49\/1\/005"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.047"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00468-3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.026"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283383b6e"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00438-6"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01607-8"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.047"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.008"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.07.027"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.05.063"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.01.001"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.25824","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.25824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:23:31Z","timestamp":1760264611000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.25824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,14]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,6,15]]}},"alternative-id":["10.1002\/cncr.25824"],"URL":"https:\/\/doi.org\/10.1002\/cncr.25824","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,14]]}}}