{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:54:38Z","timestamp":1790128478687,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T00:00:00Z","timestamp":1294617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The recurrence of hepatocellular carcinoma (HCC) after hepatectomy is a serious event. It has been demonstrated that different ground\u2010glass hepatocyte (GGH) patterns harbor specific hepatitis B virus (HBV) pre\u2010S deletion mutants and represent preneoplastic lesions in chronic HBV infection. In the current study, the authors investigated whether a specific GGH pattern in nontumorous liver tissues was associated with the recurrence of HBV\u2010related HCC after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Clinicopathologic data from 82 patients with HBV\u2010related HCC were reviewed. GGH patterns were assessed on hematoxylin and eosin\u2010stained sections. Tissue hepatitis B surface antigen (HBsAg) expression was evaluated by immunohistochemical staining. Serum profiles of pre\u2010S status, viral load, and HBV genotype were determined and correlated with clinical recurrence and survival after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The results indicated that the clustered pattern of GGHs or HBsAg expression was associated significantly with decreased local recurrence\u2010free survival (LRFS) during a mean follow\u2010up of 46.4 months (<jats:italic>P<\/jats:italic>&lt;.001). This biomarker was comparable to or better than the prognostic value of other parameters, such as multifocal tumors (<jats:italic>P<\/jats:italic> = .022), satellite nodules (<jats:italic>P<\/jats:italic> = .005), small cell dysplasia (<jats:italic>P<\/jats:italic> = .045), or elevated viral load (<jats:italic>P<\/jats:italic> = .027), to predict recurrent HCC. Multivariate analysis also revealed that type II GGHs, which expressed marginal HBsAg and consistently clustered in nodules, were independent variables associated with LRFS (<jats:italic>P<\/jats:italic>&lt;.001) and overall survival (<jats:italic>P<\/jats:italic> = .003).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The current results indicated that the assessment of GGH patterns or HBsAg expression in nontumorous liver tissues provides an easily recognized, new risk marker for the recurrence of HBV\u2010related HCC after hepatic resection. Cancer 2011. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25837","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T17:14:03Z","timestamp":1294679643000},"page":"2951-2960","source":"Crossref","is-referenced-by-count":58,"title":["A clustered ground\u2010glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery"],"prefix":"10.1002","volume":"117","author":[{"given":"Hung\u2010Wen","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Jyh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Chieh","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Hsi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jui","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Huang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ih\u2010Jen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,10]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Department of Health Taiwan. 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