{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:54:13Z","timestamp":1781243653802,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated with definitive chemoradiotherapy by either intensity\u2010modulated radiation therapy (IMRT) or conventional radiotherapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Forty\u2010six patients who received definitive chemoradiotherapy from January 1993 to August 2009 were included. Forty\u2010five patients received 5\u2010fluorouracil with mitomycin C (n = 39) or cisplatin (n = 6). Seventeen (37%) were treated with CRT and 29 (63%) with IMRT. The median dose was 54 Gy in both groups. Median follow\u2010up was 26 months (CRT) and 32 months (IMRT). T3\u2010T4 stage (<jats:italic>P<\/jats:italic> = .18) and lymph node\u2010positive disease (<jats:italic>P<\/jats:italic> = .6) were similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The CRT group required longer treatment duration (57 days vs 40 days, <jats:italic>P<\/jats:italic> &lt; .0001), more treatment breaks (88% vs 34.5%, <jats:italic>P<\/jats:italic> = .001), and longer breaks (12 days vs 1.5 days, <jats:italic>P<\/jats:italic> &lt; .0001) than patients treated with IMRT. Eleven (65%) patients in the CRT group experienced grade &gt;2 nonhematologic toxicity compared with 6 (21%) patients in the IMRT group (<jats:italic>P<\/jats:italic> = .003). The 3\u2010year overall survival (OS), locoregional control (LRC), and progression\u2010free survival were 87.8%, 91.9%, and 84.2%, respectively, for the IMRT groups and 51.8%, 56.7%, and 56.7%, respectively, for the CRT group (all <jats:italic>P<\/jats:italic> &lt; .01). On multivariate analysis, T stage, use of IMRT, and treatment duration were associated with OS, and T stage and use of IMRT were associated with LRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The use of IMRT was associated with less toxicity, reduced need for treatment breaks, and excellent LRC and OS compared with CRT in patients with SCCA of the anal canal. Cancer 2011. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25901","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T16:40:43Z","timestamp":1296578443000},"page":"3342-3351","source":"Crossref","is-referenced-by-count":130,"title":["Intensity\u2010modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal"],"prefix":"10.1002","volume":"117","author":[{"given":"Jose G.","family":"Bazan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela 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