{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:43:12Z","timestamp":1790239392017,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The objective of this study was to determine whether specific single nucleotide polymorphisms (SNPs) from nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways are associated with sensitivity to trabectedin in patients with soft tissue sarcoma (STS).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The authors analyzed excision repair cross\u2010complementation group 5\/xeroderma pigmentosum group G (<jats:italic>ERCC5\/XPG<\/jats:italic>) (NER), excision repair cross\u2010complementation group 1 (<jats:italic>ERCC1<\/jats:italic>) (NER), and breast cancer 1 (<jats:italic>BRCA1<\/jats:italic>) (HR) SNPs and messenger RNA expression levels in tumor specimens from 113 patients with advanced STS who were enrolled in previously published phase 2 trials or in a compassionate\u2010use program. The 6\u2010month progression\u2010free rate (PFR), progression\u2010free survival (PFS), and overall survival (OS) were analyzed according to <jats:italic>ERCC5, ERCC1<\/jats:italic>, and <jats:italic>BRCA1<\/jats:italic> status using log\u2010rank tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>High expression of the common allele (aspartic acid at codon 1104) of <jats:italic>ERCC5<\/jats:italic>, high expression of <jats:italic>ERCC1<\/jats:italic>, and <jats:italic>BRCA1<\/jats:italic> haplotype were associated significantly with improved PFR, PFS, and OS. The <jats:italic>ERCC1<\/jats:italic> thymine\u2010to\u2010cytosine (T\u2192C) SNP at codon 19007 and <jats:italic>BRCA1<\/jats:italic> expression were not associated with outcome. On univariate analysis, tumor histology, favorable NER status (high expression of common <jats:italic>ERCC5<\/jats:italic> and\/or high <jats:italic>ERCC1<\/jats:italic> expression status), and favorable <jats:italic>BRCA1<\/jats:italic> haplotype (at least 1 triple\u2010adenine plus guanine [AAAG] allele) were the sole variables associated significantly with PFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>In the current study, <jats:italic>ERCC5<\/jats:italic>, <jats:italic>ERCC1<\/jats:italic>, and <jats:italic>BRCA1<\/jats:italic> status represented a potential DNA repair signature that could be used for the prediction of clinical response to trabectedin in patients with STS. Cancer 2011. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25925","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T16:47:15Z","timestamp":1296578835000},"page":"3445-3456","source":"Crossref","is-referenced-by-count":56,"title":["<i>ERCC5<\/i>\/<i>XPG<\/i>, <i>ERCC1,<\/i> and <i>BRCA1<\/i> gene status and clinical benefit of trabectedin in patients with soft tissue 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