{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:36:09Z","timestamp":1784604969646,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>A study was undertaken to investigate the detection of relapse and survival outcomes in patients with cervical cancer treated with curative intent chemoradiotherapy, and evaluated with a post\u2010therapy <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET) scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Between January 2002 and June 2007, 105 consecutive patients were prospectively enrolled into a registry study designed to assess outcomes of chemoradiotherapy. A FDG\u2010PET scan was performed between 3 and 12 months (median, 4.9 months) post\u2010treatment at clinician discretion. Tumor response was graded as complete metabolic response, partial metabolic response, or progressive metabolic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Median follow\u2010up was 36 months. At post\u2010therapy FDG\u2010PET, 73 (70%) patients had complete metabolic response, 10 (9%) had partial metabolic response, and 22 (21%) had progressive metabolic disease. Overall survival at 3 years was 77% in all patients, and 95% for those with complete metabolic response. On multivariate analysis, complete metabolic response (<jats:italic>P<\/jats:italic> &lt; .0001) and pretreatment tumor volume (<jats:italic>P<\/jats:italic> = .041) were strong predictors for overall survival. The number of involved lymph nodes (<jats:italic>P<\/jats:italic> &lt; .005) and International Federation of Gynecology and Obstetrics stage (<jats:italic>P<\/jats:italic> = .04) were predictive of relapse\u2010free survival. In total, 18 patients relapsed at a single site, and 13 underwent salvage, with a 3\u2010year survival of 67%. Patients with complete metabolic response had a distant failure rate 36\u2010fold less than those with partial metabolic response (<jats:italic>P<\/jats:italic> &lt; .0001). After complete metabolic response, only 1 patient (1.6%) relapsed without symptoms and was detected through physical examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The presence of a complete metabolic response at post\u2010therapy FDG\u2010PET is a powerful predictor for survival after chemoradiation. The very low rate of recurrence in patients with a complete metabolic response justifies a conservative follow\u2010up approach for these patients, because relapse is usually symptomatic and not detected by routine clinical review. Cancer 2011. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.25991","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T20:06:36Z","timestamp":1299009996000},"page":"3981-3988","source":"Crossref","is-referenced-by-count":54,"title":["Impact of post\u2010therapy positron emission tomography on prognostic stratification and surveillance after chemoradiotherapy for cervical cancer"],"prefix":"10.1002","volume":"117","author":[{"given":"Shankar","family":"Siva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Herschtal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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