{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:08:27Z","timestamp":1790665707390,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T00:00:00Z","timestamp":1301270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Although the literature reports a low incidence of Burkitt lymphoma (BL) as a post\u2010transplant lymphoproliferative disorder (PTLD), this entity appears to be different from other monomorphic PTLDs (M\u2010PTLDs), both in its aggressive clinical presentation and its distinct pathologic profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Patients with BL, diagnosed in the post\u2010transplant setting, (patients aged \u226418 years) were retrieved from the pathology archives at Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center from 1982 to 2010. Clinical outcomes were obtained along with pathologic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Twelve patients with pediatric BL in the post\u2010transplant setting (9 boys, 3 girls) were retrieved. The patients displayed a monomorphic population of small to intermediate\u2010sized, noncleaved, lymphoid elements with a \u201cstarry\u2010sky\u201d pattern. The immunophenotype for patients available to the study was CD20+ (n = 9\/10), CD10+ (n = 8\/8), bcl\u20106+ (n = 11\/11), with a near 100% Ki\u201067\/MIB\u20101 proliferation index (n = 7\/7), and negative for TdT (n = 7\/7). Most pretransplant Epstein\u2010Barr virus titers were negative (n = 8\/10), with post\u2010transplant titers positive in all tested patients (n = 11), and with positive Epstein\u2010Barr\u2013encoded RNA in situ hybridization in most cases (n = 9\/11). The median time from transplantation to diagnosis was 52 months (range, 6\u2010107 months). Nine patients were currently alive after immediate antineoplastic chemotherapy, with median disease\u2010free time of 93 months from diagnosis (range, 2\u2010199 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>BL\u2010PTLD had a higher Epstein\u2010Barr virus incidence compared with sporadic and immunodeficiency\u2010associated BL and represented a distinct monomorphic PTLD. Although some M\u2010PTLDs can be managed less aggressively with decreased immunosuppression alone, immediate lymphoma\u2010specific chemotherapy was associated with a favorable outcome and was strongly recommended. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26001","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T18:45:39Z","timestamp":1301337939000},"page":"4540-4550","source":"Crossref","is-referenced-by-count":46,"title":["Post\u2010transplant Burkitt lymphoma is a more aggressive and distinct form of post\u2010transplant lymphoproliferative disorder"],"prefix":"10.1002","volume":"117","author":[{"given":"Jennifer","family":"Picarsic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mazariegos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve A.","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Reyes\u2010M\u00fagica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1392-x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199912270-00006"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198804000-00011"},{"key":"e_1_2_6_5_2","first-page":"262","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Leoncini L","year":"2008"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.859"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood.V82.2.619.619","article-title":"In situ demonstration of Epstein\u2010Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome\u2010related lymphomas: correlation with tumor morphology and primary site","volume":"82","author":"Hamilton\u2010Dutoit SJ","year":"1993","journal-title":"Blood."},{"key":"e_1_2_6_8_2","first-page":"15","article-title":"Histopathologic features of high\u2010grade nonHodgkin's lymphomas in acquired immunodeficiency syndrome. 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