{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:00:58Z","timestamp":1780509658534,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T00:00:00Z","timestamp":1299542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2011,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Individuals with a family history of colorectal cancer (CRC) are at increased risk for CRC. Current screening recommendations for these individuals are based on expert opinion. The authors investigated optimal screening strategies for individuals with various degrees of family history of CRC based on a cost\u2010effectiveness analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The MISCAN\u2010Colon microsimulation model was used to estimate costs and effects of CRC screening strategies, varying by the age at which screening was started and stopped and by screening interval. The authors defined 4 risk groups, characterized by the number of affected first\u2010degree relatives and their age at CRC diagnosis. For all risk groups, the optimal screening strategy had an incremental cost\u2010effectiveness ratio of approximately $50,000 per life\u2010year gained.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The optimal screening strategy for individuals with 1 first\u2010degree relative diagnosed after age 50 years was 6 colonoscopies every 5 years starting at age 50 years, compared with 4 colonoscopies every 7 years starting at age 50 years for average risk individuals. The optimal strategy had 10 colonoscopies every 4 years for individuals with 1 first\u2010degree relative diagnosed before age 50 years, 13 colonoscopies every 3 years for individuals with 2 or more first\u2010degree relatives diagnosed after age 50 years, and 15 colonoscopies every 3 years for individuals with 2 or more first\u2010degree relatives of whom at least 1 was diagnosed before age 50 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The optimal screening strategy varies considerably with the number of affected first\u2010degree relatives and their age of diagnosis. Shorter screening intervals than the currently recommended 5 years may be appropriate for the highest risk individuals. Cancer 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26009","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T14:09:40Z","timestamp":1299593380000},"page":"4166-4174","source":"Crossref","is-referenced-by-count":30,"title":["How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer?"],"prefix":"10.1002","volume":"117","author":[{"given":"Janneke A.","family":"Wilschut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout W.","family":"Steyerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"van Leerdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Lansdorp\u2010Vogelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Dik F.","family":"Habbema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"van Ballegooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.07.018"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.023"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04677.x"},{"key":"e_1_2_6_5_2","first-page":"367","article-title":"The frequency of a positive family history for colorectal cancer: a population\u2010based study in the Netherlands","volume":"64","author":"de Jong AE","year":"2006","journal-title":"Neth J Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5084"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.054"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70168-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292701"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01978.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16508"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-9-200811040-00243"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(00)00851-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50044"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1998.1498"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.7.557"},{"key":"e_1_2_6_18_2","volume-title":"Model Profiler of the MISCAN\u2010Colon microsimulation model for colorectal cancer","author":"Vogelaar I","year":"2004"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24256"},{"key":"e_1_2_6_20_2","volume-title":"Final report MISCAN\u2010COLON microsimulation model for colorectal cancer: report to the National Cancer Institute Project No. NO1\u2010CN55186","author":"Loeve F","year":"1998"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20277"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22115"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02630528"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02616606"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880401)61:7<1472::AID-CNCR2820610734>3.0.CO;2-E"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196302000-00007"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360209"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1508"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909089217"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197905)43:5<1847::AID-CNCR2820430538>3.0.CO;2-L"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820215)49:4<819::AID-CNCR2820490435>3.0.CO;2-D"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.10.835"},{"key":"e_1_2_6_33_2","volume-title":"Surveillance, Epidemiology, and End Results (SEER) Program SEER*Stat Software, version 5.3.1","author":"Surveillance Research Program","year":"2003"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.012"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70668-8"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70214-2"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70213-0"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-12-200612190-00004"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007203430301"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966182"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054967"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00678564"},{"key":"e_1_2_6_43_2","unstructured":"ZauberA Lansdorp\u2010VogelaarI WilschutJ KnudsenAB van BallegooijenMM KuntzKM.Cost\u2010effectiveness of DNA stool testing to screen for colorectal cancer: report to AHRQ and CMS from the Cancer Intervention and Surveillance Modeling Network (CISNET) for MISCAN and SimCRC Models.2007. Available at:http:\/\/www.cms.gov\/determinationprocess\/downloads\/id52TA.pdf."},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn103"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200927040-00003"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60551-X"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01157.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1294::AID-CNCR4>3.0.CO;2-M"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.018"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38606.794560.EB"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp319"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9654-y"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.4797"},{"key":"e_1_2_6_54_2","volume-title":"Colorectal Cancer Risk Assessment Tool","year":"2008"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.26009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.26009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:18:35Z","timestamp":1760271515000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.26009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,8]]},"references-count":53,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2011,9,15]]}},"alternative-id":["10.1002\/cncr.26009"],"URL":"https:\/\/doi.org\/10.1002\/cncr.26009","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,8]]}}}