{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:38:43Z","timestamp":1762004323305,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T00:00:00Z","timestamp":1310428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Single nucleotide polymorphisms (SNPs) in nucleotide excision repair (NER) pathway genes may modulate DNA repair capacity and increase susceptibility to breast cancer (BC). A case\u2010control study was conducted by evaluating genes involved in DNA repair to identify polymorphisms associated with BC.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>The 384 SNPs of 38 candidate genes were genotyped using the Illumina GoldenGate method. Genotypes were determined in a case\u2010control study that consisted of 346 BC patients and 361 controls. Odds ratios and 95% confidence intervals were computed using logistic regression models. Multiple logistic regression models adjusted for age, family history of BC, and body mass index were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Gene\u2013gene interaction analysis among the DNA repair pathway genes showed significant effects on BC risk. <jats:italic>ERCC2<\/jats:italic> rs50872 (TC genotype) in combination with <jats:italic>XPA<\/jats:italic> rs2808668 (TC genotype) and rs1800975 (AG genotype) was strongly associated with an increased risk of BC (<jats:italic>P<\/jats:italic> = .0004 and .0002, <jats:italic>P<\/jats:italic><jats:sub>Bonferroni<\/jats:sub> = .023 and .014, respectively). Moreover, the T\u2010G (including rs2808668 and rs1800975) haplotype in <jats:italic>XPA<\/jats:italic> combined with the <jats:italic>ERCC2<\/jats:italic> T allele in rs50872 carriers was also associated with additive risk effect of BC (odds ratios: 2.58, 2.62, and 3.49, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>Genetic variation in DNA repair genes involved in NER mechanisms increased the risk of BC development. These results suggested that a stronger combined effect of SNPs via gene\u2013gene interaction may help to predict BC risk. Cancer 2012;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.26220","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T17:04:46Z","timestamp":1310490286000},"page":"594-602","source":"Crossref","is-referenced-by-count":27,"title":["SNP\u2013SNP interactions between DNA repair genes were associated with breast cancer risk in a Korean 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